Even Moderate Weight Loss Helps Prevent Breast Cancer in Postmenopausal Women

Rowan Chlebowski, MD, PhD

Losing even some extra weight significantly reduces the risk of breast cancer for postmenopausal women, a researcher reported during the 2017 San Antonio Breast Cancer Symposium, held December 5-9 in San Antonio, Texas.

Compared to women whose weight remained stable, those who lost 5% or more of their body weight were 12% less likely to develop breast cancer (HR 0.88; 95% CI, 0.78-0.98), according to study results presented by Rowan Chlebowski, MD, PhD, a research professor in the Department of Medical Oncology and Therapeutics Research at City of Hope in Duarte, California. Weight loss of 15% or more was associated with a 37% reduction in breast cancer risk (HR 0.63; 95% CI, 0.45-0.90).

“In the 3-year window of the study, relatively modest weight loss was associated with significant lowering of breast cancer incidence,” Chlebowski said. “From this study, we have evidence that a weight-loss strategy can be effective in lowering breast cancer risk in postmenopausal women.”

The study enrolled 61,335 women. At baseline, 41% of them were normal weight, 34% were overweight, and 25% were obese. They were studied in 4 groups categorized by BMI, age, race/ethnicity, and history of using hormonal drugs, but no differences in outcomes were found based on these distinctions.

Of the women enrolled, 3061 developed invasive breast cancer during their follow-up period. Compared to women whose weight remained stable, those who lost 5% or more of their body weight were 12% less likely to develop breast cancer (HR 0.88; 95% CI, 0.78-0.98). Weight loss of 15% or more was associated with a 37% reduction in breast cancer risk (HR 0.63; 95% CI 0.45-0.90).

Conversely, weight gain of 5% or more was not tied to increased overall breast cancer risk—but it was associated with more than a 50% increased risk of triple-negative breast cancer (HR 1.54; 95%; 95% CI 1.16-2.05).

Protection against breast cancer was not significantly statistically different whether or not the weight loss was intentional, Chlebowski said.

“These are very optimistic findings that provide a lesson to postmenopausal women that even a moderate degree of weight loss may be associated with health benefits,” Chlebowski said. “It’s a relatively new finding, and it’s going to have public health implications.”

The results came out of a large, prospective, observational study that took note of participants’ heights and weights at baseline and again after 3 years. Investigators followed up with each woman yearly, over an average 11.4 years, to monitor for any development of breast cancer. Postmenopausal women with an anticipated survival of at least 3 years were enrolled at 40 US centers between 1993 and 1998, and data collection closed on September 30, 2015.

Chlebowski said that he and fellow investigators embarked on the study because breast cancer is a common disease and cause of death in American women, obesity rates have been increasing in the United States, and several previous studies have associated a high weight-to-height ratio, or body mass index (BMI), with increased breast cancer risk in postmenopausal women. He noted that 65% of American women are overweight or obese.

“We wanted to determine if weight loss was associated with lower breast cancer incidence, as studies have not been able to consistently show that losing weight reduces the risk of breast cancer,” Chlebowski said. Past studies used measurements that were self-reported by participants, rather than the type of clinical data collected in the City of Hope project, he said.

For this project, Chlebowski and colleagues analyzed data from the Women’s Health Initiative (WHI) Observational Study, which tracks the health of postmenopausal women between the ages of 50 and 79. Any participant in the WHI with normal mammogram results and no prior breast cancer, and who was not underweight (defined by a BMI of 18.5 k/mg2 or less), was eligible for enrollment. At baseline, in addition to height and weight data, the investigators asked participants to fill out questionnaires detailing their medical histories, breast cancer risk factors, medication use, and mammogram frequency.

To make the most of the information, he said, stakeholders in the health system will need to determine which types of experts should be responsible for helping women form and implement weight loss plans, and work to make sure that those efforts are covered by health insurance.

The study was supported by the National Institutes of Health.

Chlebowski RT, Luo J, Anderson GL, et al. Weight loss and breast cancer incidence in postmenopausal women. Presented at: the 2017 San Antonio Breast Cancer Symposium, December 5-9, 2017; San Antonio, TX. Abstract GS5-07.