Dr. Rini on the Tolerability of Atezolizumab Plus Bevacizumab in RCC

Brian I. Rini, MD, professor of medicine, Cleveland Clinic, discusses the tolerability of atezolizumab (Tecentriq) plus bevacizumab (Avastin) in renal cell carcinoma (RCC).

Among the multiple combination immunotherapy studies that are currently ongoing in RCC, the tolerability profile of atezolizumab and bevacizumab is a distinguishing feature of this regimen, Rini says. In a presentation of patient-reported outcomes from the IMmotion151 at the 2018 ASCO Annual Meeting, various scales and instruments were used to measure this. Although there are no efficacy data to show differences in activity, there are differences in tolerability between the regimens.

Previously-reported findings from the IMmotion151 study showed that the combination reduced the risk of progression or death by 26% compared to sunitinib (Sutent) in patients with untreated PD-L1—positive metastatic RCC. The average time to deterioration of a patient was about 11 months, which corresponds with the progression-free survival, Rini says.