Farhad Ravandi-Kashani, MD, professor, Department of Leukemia, The University of Texas MD Anderson Cancer Center, discusses vadastuximab talirine plus hypomethylating agents (HMA) in acute myeloid leukemia (AML).

The CD33-directed antibody-drug conjugate vadastuximab talirine showed good tolerability in a phase I single-agent trial, says Ravandi, with the only toxicity being myelosuppression.

This led to a trial combining low doses of vadastuximab talirine with HMA, given on the last day of therapy with either azacitidine or decitabine.

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European Hematology Association Congress

Farhad Ravandi-Kashani, MD, professor, Department of Leukemia, The University of Texas MD Anderson Cancer Center, discusses vadastuximab talirine plus hypomethylating agents in acute myeloid leukemia.

Dr. Ravandi on Vadastuximab Talirine Plus Hypomethylating Agents in AML