Dana E. Rathkopf, MD, Memorial Sloan Kettering Cancer Center, discusses the emergence of the androgen receptor splice variant-7 (AR-V7) biomarker in the treatment of patients with prostate cancer.

AR-V7 has been previously studied in circulating tumor cells in men with castration-resistant prostate cancer to identify primary resistance to enzalutamide (Xtandi) and abiraterone acetate (Zytiga) therapy.

AR-V7 is currently being looked at as a biomarker to find an appropriate patient population, wherein physicians then may be able to use combinations of other drugs to overcome resistance to targeted therapy.

According to Rathkopf, biomarkers like this are the key to understanding and mitigating resistance in prostate cancer.

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The OncLive Prostate Cancer condition center page is a comprehensive resource for clinical news and expert insights on how to approach treatment for patients with nonmetastatic, castration-resistant, or castration-sensitive prostate cancer. This page features news articles, interviews in written and video format, and podcasts that focus on unmet needs, ongoing research, and treatment advances with androgen receptor inhibitors, PARP inhibitors, and more in prostate cancer.

Dr. Rathkopf on AR-V7 Biomarker in Prostate Cancer