Dr. Rampal on Pelabresib With or Without Ruxolitinib in Myelofibrosis

Raajit K. Rampal, MD, PhD, hematologic oncologist, Memorial Sloan Kettering Cancer Center, discusses the investigation of pelabresib (CPI-0610) with or without ruxolitinib (Retuxan) in patients with myelofibrosis.

The phase 1/2 MANIFEST trial (NCT02158858) examined the use of pelabresib with and without ruxolitinib in patients with myelofibrosis. The MANIFEST study featured 3 arms: the combination of pelabresib and ruxolitinib in previously untreated patients, single-agent pelabresib in patients who were already receiving ruxolitinib, and single-agent pelabresib arm for patients previously treated with a JAK inhibitor, Rampal explains.

Data showed that in the up-front treatment setting, patients treated with the combination experienced a benefit in spleen volume response—defined as a 35% or greater reduction in spleen volume—compared favorably with historical data for single-agent ruxolitinib, Rampal adds.

The phase 3 MANIFEST-2 trial (NCT04603495) will further investigate the combination of pelabresib and ruxolitinib vs placebo plus ruxolitinib in patients with myelofibrosis who have not received prior treatment with a JAK inhibitor, Rampal concludes.