Dr. Melnick on the Epigenetic Basis of B-Cell Lymphomas

Ari M. Melnick, MD, Professor of Medicine, Weill Cornell Medical College, discusses his presentation on the epigenetic basis of B-cell lymphomas at the 17th International Congress on Hematologic Malignancies.

Melnick says that epigenetic gene regulation functions as the software that guides cells towards behavior and that this 'software' is crucial for survival and growth.

Lymphoma cells are no different than other cell types in that they require epigenetic modifications and certain patterns (or epigenetic landscapes) to exhibit the classical phenotype of lymphoma subtypes. These epigenetic marks include cytosine methylation, histone modifications, and other components of the epigenome.