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Dr. Khushalani on the Mechanism of Action of RP1 in Cancer Care

Nikhil Khushalani, MD, discusses the mechanism of action vusolimogene oderparepvec in cancer care.

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    Nikhil Khushalani, MD, vise chair, Department of Cutaneous Oncology, Moffitt Cancer Center, discusses the mechanism of action vusolimogene oderparepvec (RP1) in cancer care.

    RP1 is a next generation of talimogene laherparepvec (T-VEC; Imlygic), Khushalani says. RP1 is a selectively replication-specific herpes simplex virus-1 (HSV-1) for intertumoral injection, Khushalani says. What differentiates RP1 from T-VEC is the presence of a construct of HSV-1 where the neurovirulence factor gene has been deleted, allowing the virus to replicate within the tumor cells without harming normal cells through a bystander effect, Khushalani explains. Additionally, a granulocyte-macrophage colony-stimulating factor payload is encoded into RP1 to directly destroy tumors and generate an antitumor immune response, Khushalani adds.

    RP1 also features an encoding codon for the glycoprotein, GALV-GP, with the deletion of the R sequence, Khushalani continues. This promotes cell-to-cell adhesion-related cytotoxicity, and tumor cells that are adjacent to one another when exposed to the agent undergo cytotoxic death, Khushalani concludes.


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