Mohammad Jahanzeb, MD, professor of Clinical Medicine, Hematology/Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, discusses the APHINITY and ExteNET studies in breast cancer.

The APHINITY study investigated the dual HER2 blockade of pertuzumab (Perjeta) and trastuzumab (Herceptin) plus chemotherapy. In the metastatic setting, there was data showing these 2 antibodies result in some additional toxicities, however, they have not been shown to cause much incremental cardiotoxicity, Jahanzeb explains.

The trial completed accrual in August of 2013, and while results are expected this year, they are not yet available. However, Jahanzeb says, it has been announced that the results are positive.

Five-year data for the ExteNET study, which investigated neratinib following trastuzumab, also looks positive, similar to the previously reported 2-year and 3-year data, Jahanzeb says.

View more from the 2017 Miami Breast Cancer Conference

Conference

® Conference page includes a listing of all conferences covered by 

, including the ASCO, ESMO, SITC, EHA, ASH, and SABCS annual meetings, as well as the Chemotherapy Foundation Symposium and Miami Breast Cancer Conference, among many others. Conference coverage incorporates articles and interviews in written and video format.


Breast Cancer

 Breast Cancer condition center page is a comprehensive resource for clinical news and expert insights on various types of breast cancer, including those that are triple negative, hormone receptor positive, and/or HER2 positive. This page features news articles, interviews in written and video format, and podcasts that focus on treatment advances and ongoing research in breast cancer.

Dr. Jahanzeb on the APHINITY and ExteNET Trials in Breast Cancer