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Dr. Giralt on Omidubicel Vs Standard Umbilical Cord Blood Transplant in Hematologic Malignancies

Sergio A. Giralt, MD, discusses the results of a phase 3 trial comparing omidubicel with standard umbilical cord blood transplant in hematologic malignancies.

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    Sergio A. Giralt, MD, deputy division head, Division of Hematologic Malignancies, Melvin Berlin Family Chair in Multiple Myeloma, Memorial Sloan Kettering Cancer Center, discusses the results of a phase 3 trial (NCT02730299) comparing omidubicel with standard umbilical cord blood transplant (UCBT) in hematologic malignancies.

    During the 47th Annual Meeting of the EBMT, the results of a phase 3 trial of omidubicel, a cryopreserved cellular product derived from a single umbilical cord blood unit and expanded ex vivo, vs standard UCBT in patients with high-risk hematologic malignancies following myeloablation were presented virtually. The findings demonstrated a 124-fold improvement in CD34-positive cell expansion with omidubicel vs UCBT at 9 x 106 cells/kg and 0.3 x 106 cells/kg, respectively. The median time to neutrophil engraftment was 12 days with omidubicel vs 22 days with UCBT. Non-relapse mortality at 180 days after treatment, 1-year relapse rate, and 1-year probability of overall survival did not differ significantly between arms but favored omidubicel.

    Additionally, patients who received omidubicel had a higher incidence of 42-day platelet engraftment, a lower incidence of grade 2 or 3 bacterial or invasive fungal infection, and spent less time hospitalized within 100 days after transplant compared with standard UBCT.

    Comparative trials of omidubicel vs haploidentical transplant with post-transplant cyclophosphamide could shed additional light on the utility of omidubicel in this patient population, concludes Giralt.


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