Dr. Chen Explores Possible Genomic Basis for Racial Disparities in CTCL Outcomes

Pei-Ling Chen, MD, PhD, is a member of the Pathology and Cutaneous Oncology Departments at Moffitt Cancer Center and a member of the Moffitt Cutaneous Lymphoma Multidisciplinary Clinic specializing in the research and treatment of cutaneous T-cell lymphoma (CTCL).

Dr. Chen recently published results of a multiomics profiling of 56 patients with transformed CTCL that may represent the first time investigators have identified a potential genomic cause for poorer outcomes for Black patients with CTCL.

Investigators determined that, compared with White patients, Black patients showed a reduced UV signature and enrichment of a unique signature cluster with DNA mismatch repair. Chen and her collegues speculate that these factors drive the race-based disparity in outomes in CTCL.