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Dr Arora on Findings From a SEER Database Analysis in Mantle Cell Lymphoma

Ruby Arora, MD, discusses findings from a SEER database analysis of mantle cell lymphoma incidence rates from 2000 to 2021.

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    “[These findings] were a new [trend] being reported. In the past, it was reported that the incidence of MCL was increasing, and our data [indicate] that it is actually following the overall [incidence] trend of NHL, which is trending downward.”

    Ruby Arora, MD, a resident physician of internal medicine in the Department of Medicine at the University of Illinois College of Medicine, discussed data from an analysis of the Surveillance, Epidemiology, and End Results (SEER) database of patients with mantle cell lymphoma (MCL) presented during the 2025 ASCO Annual Meeting.

    To conduct their analysis, Arora and coauthors included data from patients with MCL included in the SEER database from 22 US states from 2001 to 2021. The investigators had previously reported that the rate of MCL incidence has been declining at a statistically significant rate since 2015.

    The study authors primarily examined the annual percent change of the incidence of MCL in 5-year periods, Arora began. Data from the study showed that the overall incidence of MCL in the US has continued to decline in a statistically significant manner, she said. These findings are in line with the overall decrease of the incidence of non-Hodgkin lymphoma (NHL), Arora added. In the past, reports had indicated that the incidence of MCL was increasing, but these new data suggest it is following the same downward trend as NHL, she concluded.

    Data from the study demonstrated that the annual percentage change in MCL incidence from 2000 to 2014 was 2.03%, but from 2015 to 2021, the annual percentage change was –1.427%. An initial increase in MCL incidence was reported from 0.684 cases per 100,000 individuals per year from 2000 to 2004, to 0.786 cases per 100,000 individuals per year from 2005 to 2009, which then rose to 0.845 cases per 100,000 individuals per year from 2010 to 2014. However, from 2015 to 2019, this figure fell to 0.828 cases per 100,000 individuals per year, fell further to 0.783 cases per 100,000 individuals in 2020, and finally fell to 0.778 cases per 100,000 individuals in 2021.


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