Updates in Immunotherapy for Non–Small Cell Lung Cancer

The latest research and impact of recent clinical trials on treatment selection using immunotherapy-based regimens for metastatic non–small cell lung cancer (NSCLC), consolidation immunotherapy in stage III disease, and perioperative regimens with immunotherapy in resectable NSCLC.

EP. 1: Frontline Treatment of PD-L1+ Stage IV NSCLC: Cemiplimab

June 30th 2021

Roy S. Herbst, MD, PhD, of Yale Cancer Center, highlights treatment advances in stage IV non–small cell lung cancer, including cemiplimab as frontline monotherapy based on EMPOWER-Lung 1.

EP. 2: Frontline I-O Monotherapy Versus Combination Therapy for PD-L1+ Stage IV NSCLC

June 30th 2021

Drs Roy S. Herbst and Sandip P. Patel comment on patient candidacy for immunotherapy as monotherapy to treat PD-L1+ metastatic non–small cell lung cancer versus chemoimmunotherapy.

EP. 3: Frontline Treatment of Stage IV NSCLC: IPI/NIVO

July 7th 2021

Neal Edward Ready, MD, PhD, describes which patients with stage IV non–small cell lung cancer may benefit from the combination of ipilimumab and nivolumab in the frontline treatment setting.

EP. 4: Frontline Treatment Decisions for Stage IV NSCLC

July 7th 2021

Considerations for selecting frontline therapy for metastatic non–small cell lung cancer based on various new data and treatment approvals in the field of immunotherapy.

EP. 5: Frontline Treatment of Stage IV NSCLC: Biomarkers

July 14th 2021

Martin Dietrich, MD, PhD, shares his thoughts on PD-L1 status, tumor mutational burden, and other predictive and prognostic biomarkers when making treatment decisions for patients with stage IV non–small cell lung cancer.

EP. 6: Immune-Related Adverse Events in NSCLC

July 14th 2021

Recommendations for managing immune-related adverse events associated with checkpoint inhibitors used to treat stage IV non–small cell lung cancer.

EP. 7: Frontline Treatment of Stage IV NSCLC: What’s Next?

July 21st 2021

Future projections regarding the role of novel I-O therapies as frontline treatment for patients with metastatic non–small cell lung cancer.

EP. 8: Second-Line Therapy for Stage IV NSCLC

July 21st 2021

Second-line treatment recommendations for patients with stage IV non–small cell lung cancer who experience disease progression after immunotherapy.

EP. 9: Durvalumab for Unresectable Stage III NSCLC

July 28th 2021

Chaitali Nangia, MD, of the Patty and George Hoag Cancer Center, reacts to the significance of the 5-year overall survival data for the PACIFIC trial evaluating the use of durvalumab after chemoradiation as treatment for inoperable stage III non–small cell lung cancer.

EP. 10: Risks of Pneumonitis in Unresectable Stage III NSCLC

July 28th 2021

How to differentiate whether a patient with unresectable stage III non–small cell lung cancer develops pneumonitis from chemoradiation or durvalumab, and insight regarding techniques to help manage treatment toxicities.

EP. 11: Appropriateness for Durvalumab in Unresectable Stage III NSCLC

August 4th 2021

Variables that influence patient selection for durvalumab consolidation after CRT as part of treatment for unresectable stage III non–small cell lung cancer.

EP. 12: CRT and I-O for Unresectable Stage III NSCLC

August 4th 2021

Martin Dietrich, MD, PhD, describes his interpretations of the KEYNOTE-799 study of pembrolizumab plus chemoradiation therapy for unresectable stage III non–small cell lung cancer.

EP. 13: Neoadjuvant Immunotherapy for Resectable NSCLC

August 11th 2021

Martin Dietrich, MD, PhD, describes his interpretations of the KEYNOTE-799 study of pembrolizumab plus chemoradiation therapy for unresectable stage III non–small cell lung cancer.

EP. 14: Clinical Endpoints and Neoadjuvant Therapy for Resectable NSCLC

August 11th 2021

The impact of endpoints used in clinical trials of neoadjuvant therapy for resectable non–small cell lung cancer as they relate to newer drug approvals and real-world practice.

EP. 15: Atezolizumab After Adjuvant Chemotherapy in Resectable NSCLC

August 18th 2021

Dr Martin Dietrich comments on the IMpower010 trial of atezolizumab versus best supportive care after adjuvant chemotherapy in patients with resected non–small cell lung cancer.

EP. 16: Biomarkers for Immunotherapy in Resectable NSCLC

August 18th 2021

Dr Roy S. Herbst comments on the utilization of biomarkers and information needed to help aid in treatment decisions about perioperative therapy for patients with resectable non–small cell lung cancer.

EP. 17: Perioperative Approaches to NSCLC

August 25th 2021

Drs Chaitali Nangia and Sandip P. Patel debate between best treatment approaches for patients with non–small cell lung cancer in the perioperative setting.

EP. 18: Blood-Based Biomarkers in NSCLC

August 25th 2021

The potential clinical utility of blood-based biomarkers in non–small cell lung cancer based on recent data presented at ASCO 2021.

EP. 19: Immunotherapy for NSCLC: Clinical Pearls

August 25th 2021

Final takeaways from ASCO 2021 and the use of immunotherapy to treat various types of patients with non–small cell lung cancer.