Transplant-Associated Thrombotic Microangiopathy

EP. 1: Overview of Transplant-Associated Thrombotic Microangiopathy (TA-TMA)

March 18th 2021

Jeffrey Laurence, MD, provides an overview of transplant-associated thrombotic microangiopathy (TA-TMA), the associated risk factors, and the role of the complement pathway in TA-TMA development.

EP. 2: Incidence of TA-TMA

March 18th 2021

Parameswaran Hari, MD, reviews challenges in defining the incidence of transplant-associated thrombotic microangiopathy; an expert panel comments on the volume of autologous transplants performed in expert centers.

EP. 3: Criteria for Diagnosing TA-TMA

March 25th 2021

A panel of experts in hematopoietic stem cell transplantation examine their personal experience in the incidence of transplant-associated thrombotic microangiopathy in the adult and pediatric populations and the criteria used to diagnose.

EP. 4: Time Frame for Development of TA-TMA

March 25th 2021

The expert panel considers the time frame of transplant-associated thrombotic microangiopathy, the subtle signs to pay attention to, and testing for proteinuria.

EP. 5: Uncontrolled Versus Self-Limited TA-TMA

April 1st 2021

Parameswaran Hari, MD, and Christine Duncan, MD, discuss the differences between uncontrolled vs self-limited transplant-associated thrombotic microangiopathy.

EP. 6: Risk Factors Associated With TA-TMA

April 1st 2021

Jeffrey Laurence, MD, reviews the risk factors for developing transplant-associated thrombotic microangiopathy, and the panel discusses how risk affects their decision to change or modify treatment regimens.

EP. 7: Relationship Between TA-TMA Development and GVHD

April 8th 2021

The panel considers the development, morbidity, and survival of transplant-associated thrombotic microangiopathy associated with GVHD (graft-versus-host disease).

EP. 8: Challenges of Accurate Diagnosis of TA-TMA After Hematopoietic Stem Cell Transplant

April 8th 2021

A panel of experts recall the challenges of accurate early detection of transplant-associated thrombotic microangiopathy and its importance for improved patient outcomes.

EP. 9: Interventions Used for TA-TMA

April 15th 2021

Jeffrey Laurence, MD, reviews the available interventions used to mitigate or treat transplant-associated thrombotic microangiopathy.

EP. 10: Practical Experience in TA-TMA Interventions

April 15th 2021

Experts in the field of hematopoietic stem cell transplantation provide their views and experiences with various interventions for managing transplant-associated thrombotic microangiopathy.

EP. 11: TA-TMA Treatment: Alternative Medications

April 22nd 2021

The panel reviews therapeutic options for managing transplant-associated thrombotic microangiopathy and the challenges associated with currently existing agents.

EP. 12: Role of Leptin in the MASP-2 Pathway

April 22nd 2021

Jeffrey Laurence, MD, discusses the role of leptin in the MASP-2 pathway as well as coagulation and complement pathways.

EP. 13: Narsoplimab: The Phase 2 Trial

April 29th 2021

Samer Khaled, MD reviews the design, results, and practical implications of the pivotal phase 2 trial of narsoplimab, a MASP-2 targeted monoclonal antibody under investigation for the treatment of thrombotic microangiopathy associated with hematopoietic stem cell transplantation.

EP. 14: Narsoplimab Trial Results

April 29th 2021

The panel of transplant experts discuss the results of the phase 2 trial of narsoplimab and the pending FDA approval of this agent for treatment of transplant-associated of thrombotic microangiopathy.

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