Expert Insights On An Evolving Treatment Landscape In Multiple Myeloma: Updates From EHA 2025

Sagar Lonial, MD, FACP, FASCO; Adrianna Rossi, MD; Ajay K. Nooka, MD, MPH, FACP; and Cesar Rodriguez, MD, discuss how evolving treatment strategies in multiple myeloma are shifting toward quadruplet therapy regimens for newly diagnosed patients, with CAR T-cell therapy being used increasingly in earlier lines of treatment for high-risk disease. They emphasize the importance of achieving MRD negativity and personalizing treatment approaches based on patient fitness rather than strict transplant eligibility criteria.