EGFR mutated NSCLC: Treatment Advances and Highlights from ASCO 2025

Panelists discuss the latest data on first-line treatment options for EGFR-mutated NSCLC, including CNS efficacy, and explore strategies for managing adverse events and sequencing therapies to optimize long-term outcomes.

EP. 1: EGFR-mutated NSCLC: Evolving Treatment Landscape

June 17th 2025

Panelists discuss evolving first-line strategies for EGFR-mutant NSCLC, highlighting the expanding role of combination regimens, CNS efficacy, and the need for personalized treatment selection and toxicity management, especially in younger, well-informed patients.

EP. 2: FLAURA2 Updated Key Outcomes and it's Clinical Impact

June 17th 2025

Panelists discuss how the FLAURA2 trial has reshaped EGFR-mutant NSCLC treatment by demonstrating meaningful progression-free survival gains with osimertinib plus chemotherapy, while emphasizing the importance of protocol adherence, long-term outcome potential, and the ongoing pursuit of curative strategies.

EP. 3: MARIPOSA: Clinical Implications of Updated Key Data

June 24th 2025

Panelists discuss the Mariposa trial’s landmark overall survival benefit with amivantamab plus lazertinib over osimertinib monotherapy in EGFR-mutant NSCLC, marking a paradigm shift toward durable survival and reinforcing the value of optimized patient selection and adherence to combination regimens.

EP. 4: FLAURA2 and MARIPOSA: Factors for Consideration when Choosing Optimal Therapy

June 24th 2025

Panelists discuss how the availability of three frontline options for EGFR-mutant NSCLC has complicated treatment selection, prompting highly individualized, hour-long consultations that balance disease biology, patient values, and the trade-offs between monotherapy and combination regimens.

EP. 5: CNS Data from FLAURA2 and MARIPOSA

July 1st 2025

Panelists discuss the evolving management of CNS metastases in EGFR-mutant lung cancer, highlighting how third-generation TKIs and combination regimens from the FLORA and Mariposa trials delay CNS progression and reduce new brain metastases, supporting a shift away from upfront radiation in asymptomatic patients.

EP. 6: Monitoring Therapies in Patients with CNS Involvement

July 1st 2025

Panelists discuss the critical role of regular brain MRI monitoring in EGFR-mutant lung cancer, balancing timely detection of intracranial progression with the risks of early radiation; they emphasize individualized treatment sequencing guided by progression patterns and resistance profiling through biopsies and liquid biopsies to optimize patient outcomes.

EP. 7: FLAURA2 and MARIPOSA: Expert Insights on Safety Outcomes

July 8th 2025

Panelists discuss the evolving safety profiles of first-line EGFR-mutated lung cancer treatments, highlighting that chemotherapy combinations cause expected hematologic toxicities and fatigue, while bispecific antibody regimens bring unique challenges such as infusion reactions, more severe rashes and diarrhea, peripheral edema, and a notably increased risk of venous thromboembolism that warrants prophylactic anticoagulation and careful patient monitoring.

EP. 8: Adverse Event Management Strategies for FLAURA2 and MARIPOSA: Expert Insights and Best Practices

July 8th 2025

Panelists discuss that chemotherapy plus osimertinib requires managing early hematologic toxicities and EGFR-related rash and diarrhea with close monitoring, while the bispecific antibody regimen involves proactive prevention of infusion reactions, anticoagulation for VTE risk, and intensive rash management to support treatment adherence and patient quality of life.

EP. 9: Mitigating Potential IRRs with Amivantamab: Clinical Insights from the SKIPPirr

July 15th 2025

Panelists discuss that the skipper regimen—a prophylactic dexamethasone schedule started days before infusion—has significantly reduced infusion-related reactions from about 66% to 22%, improving patient comfort and clinic workflow while emphasizing ongoing education and early management to ensure safety.

EP. 10: Propylactic Strategies in Managing Dermatologic AEs with Amivantamab: Expert Insights from the COCOON Trial

July 15th 2025

Panelists discuss that the Cocoon trial’s four-part prophylactic regimen—including oral antibiotics, clindamycin topical treatment, nail toxicity prevention, and ceramide-based lotions—significantly reduces skin toxicities like scalp rashes in EGFR inhibitor therapies, emphasizing the importance of patient and provider education to ensure adherence and improve treatment tolerability.

EP. 11: Mechanisms of Resistance: FLAURA2 and MARIPOSA

July 22nd 2025

Panelists discuss that resistance to frontline osimertinib is diverse, involving on-target mutations like C797S, MET amplification, and small cell transformation, highlighting the need for tissue biopsies alongside liquid biopsies to guide treatment, and note that newer combination therapies such as Mariposa may reduce certain resistance mutations and alter tumor evolution, offering hope for improved outcomes.

EP. 12: Upon Progression: Impact of Molecular Testing and Identification of MET Amplification

July 22nd 2025

Panelists discuss that managing systemic progression in EGFR-mutant lung cancer requires thorough molecular profiling via tissue and liquid biopsies to identify resistance mechanisms like histologic transformation and MET amplification, with comprehensive testing guiding next-line targeted therapies or clinical trial enrollment to optimize patient outcomes.

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