All Oncology News

The OncLive® News page includes the latest in clinical oncology news, including breaking regulatory decisions, clinical trial findings, pivotal and practice-changing data published in academic peer-reviewed journals, and more across solid and hematologic malignancies. Regulatory news includes new drug approvals by the FDA and European Union, priority review and breakthrough therapy designations, and orphan drug and fast track statuses.

Personalizing Treatment for Atypical EGFR-Mutated NSCLC

July 25th 2025

Sukhmani Padda, MD, discusses ways in which evolving treatment paradigms are tailoring treatment to target atypical EGFR alterations in NSCLC.

Understanding Underlying Resistance Mechanisms is Vital for Guiding Treatment Selection Post-Osimertinib in EGFR+ NSCLC

July 25th 2025

Heather Wakelee, MD, discusses underlying resistance mechanisms and potential therapies for EGFR+ NSCLC following osimertinib.

High-Risk Features Could Guide Treatment Intensification in First-Line EGFR-Mutated NSCLC

July 25th 2025

Lyudmila A. Bazhenova, MD, discusses considerations for treatment intensification in patients with EGFR-mutated NSCLC.

Isatuximab Plus VRd Approved in Europe for Transplant-Eligible Newly Diagnosed Multiple Myeloma

July 25th 2025

The European Commission has approved isatuximab plus VRd in transplant-eligible newly diagnosed multiple myeloma.

CHMP Recommends EU Approval of Vorasidenib for IDH1/2-Mutant Grade 2 Glioma

July 25th 2025

The CHMP has issued a positive opinion for the use of vorasidenib in IDH1/IDH2-mutant grade 2 glioma

Global Rise in Many Early-Onset GI Cancers Detailed in Two Dana-Farber Reviews, With Colorectal Cancer Leading the Trend

July 25th 2025

Fewer than 1 in 5 U.S. adults aged 45-49 screened for colorectal cancer, despite guidelines

FDA Grants Fast Track Designation to VS-7375 for KRAS G12D–Mutated Advanced Pancreatic Cancer

July 25th 2025

VS-7375 earned FDA fast track designation for KRAS G12D–mutant pancreatic ductal adenocarcinoma.

Sonrotoclax Plus Zanubrutinib Generates Durable Responses in R/R Mantle Cell Lymphoma

July 25th 2025

The combination of sonrotoclax and zanubrutinib produced deep and durable responses in relapsed/refractory mantle cell lymphoma.

Cabozantinib Wins EU Approval for Previously Treated Advanced Pancreatic and Extrapancreatic Neuroendocrine Tumors

July 24th 2025

The European Commission has approved cabozantinib for the treatment of patients with pancreatic and extrapancreatic neuroendocrine tumors.

Ongoing Research Aims to Alter Management of HR+ Breast Cancer After Frontline CDK4/6 Inhibition

July 24th 2025

Laura Huppert, MD, outlines additional information needed to implement the SERENA-6 approach in hormone receptor–positive breast cancer.

Beckerle Steps Down After 20 Years of Distinguished Service as CEO

July 24th 2025

The CEO of Huntsman Cancer Institute is stepping down after holding the role since 2006.

Belantamab Mafodotin Combos Receive EU, Canadian Approval for R/R Myeloma

July 24th 2025

The European Commission and Health Canada have approved belantamab mafodotin-based combinations for relapsed/refractory multiple myeloma.

FDA Approves Generic Ibrutinib Tablets for B-Cell Malignancies

July 24th 2025

The FDA has approved a generic version of ibrutinib tablets for B-cell malignancies.

FDA Grants Priority Review to Resubmitted BLA for Tabelecleucel in EBV+ Post-Transplant Lymphoproliferative Disease

July 24th 2025

Tabelecleucel earned FDA priority review for EBV-positive post-transplant lymphoproliferative disease following a January 2025 complete response letter.

Elironrasib Receives FDA Breakthrough Therapy Designation for Pretreated KRAS G12C+ NSCLC

July 24th 2025

The FDA has granted breakthrough therapy designation to elironrasib for KRAS G12C–mutated advanced NSCLC previously treated with chemotherapy and immunotherapy.

IHC Testing May Enable Expedited Identification of TP53-Mutant MDS and AML

July 24th 2025

Shyam A. Patel, MD, PhD, and Jonathan M. Gerber, MD, discuss the use of IHC testing for earlier identification of TP53 mutations in MDS and AML.

Prospective Cohort Study Highlights QOL Benefits of Surgery for Bone Metastases in Advanced Cancer

July 24th 2025

R. Lor Randall, MD, FACS, discusses when to intervene prophylactically in patients with advanced cancer and skeletal metastases.

Cellular Therapies Begin to Make Their Mark in Solid Tumors

July 24th 2025

OncLive spoke with experts working to develop cellular therapies in solid tumors to gain insights into their current standing and future in the space.

TQB2930 Plus Chemo Drives Responses in Pretreated HER2+ Metastatic Breast Cancer

July 23rd 2025

The novel bispecific antibody TQB2930 plus chemotherapy elicited responses in heavily pretreated HER2-positive breast cancer.

Real-World Treatment Gaps in mCRPC Reinforce the Need for Personalized Selection and Sequencing

July 23rd 2025

Jue Wang, MD, discusses persisting gaps between clinical advances and real-world care and the evolving role of personalized treatment strategies in mCRPC.