All Oncology News

The OncLive® News page includes the latest in clinical oncology news, including breaking regulatory decisions, clinical trial findings, pivotal and practice-changing data published in academic peer-reviewed journals, and more across solid and hematologic malignancies. Regulatory news includes new drug approvals by the FDA and European Union, priority review and breakthrough therapy designations, and orphan drug and fast track statuses.

Nivolumab/Chemo Combination Sustains Survival Improvement in Gastric/GEJ Cancers

January 18th 2024

Nivolumab plus chemotherapy improved PFS and OS vs chemotherapy alone in patients with advanced gastric, gastroesophageal junction, and esophageal cancers, according to 4-year data from the phase 3 CheckMate 649 study.

First-Line Nivolumab Plus Chemotherapy Shows Real-World Efficacy in Gastric/GEJ/Esophageal Cancers

January 18th 2024

Real-world findings demonstrated a favorable survival benefit with nivolumab plus chemotherapy in advanced gastroesophageal adenocarcinoma.

FDA Accepts PMA Application Seeking Approval of TTFields Therapy in NSCLC for Filing

January 18th 2024

A PMA application seeking approval of TTFields to standard therapies in patients with non–small cell lung cancer has been accepted for filing by the FDA.

Fox Chase Cancer Center Recognized for Outstanding Achievement by ECOG-ACRIN Cancer Research Group

January 18th 2024

Fox Chase Cancer Center was recognized by the ECOG-ACRIN Cancer Research Group for outstanding achievement in accrual, scientific contribution, and more.

The Role of Genetics in Cancer Care Continues to Expand

January 18th 2024

Genetic screening and testing have only recently become an integral part of cancer care.

Continued Investigations are Pertinent for FDA Approvals in the Treatment of Patients With EGFR-mutated NSCLC

January 18th 2024

Jason Porter, MD, discusses the implications of adjuvant EGFR TKI use, the importance of the potential FDA approval of osimertinib in EGFR+ NSCLC, & more.

Frontline Camrelizumab/Rivoceranib Combination Shows Promise in Unresectable HCC

January 17th 2024

Amit Mahipal, MD, discusses data on camrelizumab plus rivoceranib in advanced HCC and the phase 3 CARES-310 trial, which is currently enrolling patients.

Disitamab Vedotin Combos Show Efficacy in HER2+ and HER2-Low Breast Cancers

January 17th 2024

Disitamab vedotin alone and with ICIs, TKIs, or other antiangiogenic agents had consistent efficacy in patients with HER2-positive or -low breast cancers.

Ruvidar Demonstrates Potential for Durable Responses in Non–Muscle Invasive Bladder Cancer

January 17th 2024

Treatment with TLD-1433 led to 6-, 12-, and 15-month CR rates of 54%, 38%, and 37%, respectively, in patients with non–muscle invasive bladder cancer.

Emerging BTK-Directed Therapies Continue to Advance the Management of CLL

January 17th 2024

Michael Choi, MD, discusses several key considerations for the treatment of chronic lymphocytic leukemia.

FDA Grants Fast Track Status to NX-5948 for Relapsed/Refractory CLL/SLL

January 17th 2024

The FDA has granted fast-track status to NX-5948 for use in relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.

Carrum Health and Florida Cancer Specialists & Research Institute Partner on Breast Cancer Treatment Model

January 17th 2024

The value-based care program offers Florida patients access to high quality cancer care while reducing costs for employers

AURKA Pathway Gains Ground as Targetable Option in Metastatic Breast Cancer

January 17th 2024

As novel drugs targeting the AURKA pathway continue to advance through the development pipeline, alisertib has emerged as an agent of particular note.

Grivas Expands on Therapeutic Developments and Future Research Directions in GU Cancers

January 17th 2024

Petros Grivas, MD, PhD, discusses the role of PARP inhibitor regimens in prostate cancer, the importance of genetic testing in this setting, and more.

Lonial Reviews 2023 Highlights for Multiple Myeloma, Forecasts 2024 Research Interests

January 16th 2024

Sagar Lonial, MD, FACP, details agents of interest outside CAR T-cell therapies in multiple myeloma, including elranatamab and talquetamab.

Randall Highlights the Evolving Role of Surgery in TGCT Management

January 16th 2024

R. Lor Randall, MD, FACS, discusses the early efficacy seen with vimseltinib monotherapy and pexidartinib plus surgery in tenosynovial giant cell tumors.

Sacibertinib Plus Endocrine Therapy Shows Early Safety, Activity in ER+/HER2+ Breast Cancer

January 16th 2024

Sacibertinib plus endocrine therapy had acceptable safety with early clinical activity in patients with ER+/HER2+ metastatic breast cancer.

Frontline Tamibarotene Plus Venetoclax and Azacitidine Induces 100% CR Rate in SELECT-AML-1 Trial

January 16th 2024

Tamibarotene plus venetoclax/azacitidine elicited higher responses rates vs venetoclax/azacitidine in RARA-overexpressed acute myeloid leukemia.

GB2064 Displays Preliminary Efficacy, Tolerability in Myelofibrosis

January 16th 2024

GB2064 displayed efficacy with a generally acceptable tolerability profile in the treatment of patients with myelofibrosis.

European Commission Approves Subcutaneous Atezolizumab With Enhanze for Several Cancers

January 16th 2024

The European Commission granted marketing authorization for SC atezolizumab co-formulated with Enhanze for all approved indications of IV atezolizumab.