Optimizing R/R CLL Treatment: Therapy Sequencing and Supportive Care Strategies

Nitin Jain, MD, and Joanna M. Rhodes, MD, MDCS, discuss how various aspects of chronic lymphocytic leukemia (CLL) management are approached, including treatment selection based on prior therapies and patient factors, the use of novel agents such as pirtobrutinib, strategies for relapsed/refractory (R/R) disease, treatment sequencing, and the role of multidisciplinary teams in optimizing patient care and outcomes.

EP. 1: The Current Treatment Landscape for R/R CLL

October 15th 2024

Panelists discuss the current standard of care and treatment landscape for patients with chronic lymphocytic leukemia.

EP. 2: Impact of Prior BTKi vs BCL2i Therapy on Treatment Decision-Making in CLL

October 15th 2024

Panelists discuss how the choice of prior therapy between BTK inhibitors and BCL2 inhibitors influences subsequent treatment decisions in chronic lymphocytic leukemia (CLL), considering factors such as resistance mechanisms, toxicity profiles, and patient-specific characteristics.

EP. 3: Key Patient-Specific Factors Guiding Treatment Selection in CLL

October 22nd 2024

Panelists discuss how various patient-specific factors, including age, comorbidities, performance status, disease aggressiveness, symptoms, and biomarkers, are carefully considered to guide the selection of optimal treatment strategies for individuals with chronic lymphocytic leukemia (CLL).

EP. 4: Tailoring Treatment Approaches for Rapid vs. Slow Disease Progression in CLL

October 22nd 2024

Panelists discuss how treatment approaches are tailored differently for patients with rapid, aggressive chronic lymphocytic leukemia progression versus those with slower, less aggressive disease, considering factors such as urgency of intervention, choice of therapy intensity, and long-term management strategies.

EP. 5: Assessing Resistance to First-Line BTK Inhibitor Therapy: The Emergine Role of Testing in CLL

October 29th 2024

Panelists discuss how they assess patients for resistance to first-line BTK inhibitor therapy in chronic lymphocytic leukemia, emphasizing the importance of clinical evaluation, laboratory testing, and genetic analysis in determining the presence and mechanisms of resistance to guide subsequent treatment decisions.

EP. 6: Pirtobrutinib in the Management of R/R CLL: Updates from the BRUIN Trial

October 29th 2024

Panelists discuss how the non-covalent BTK inhibitor pirtobrutinib has shown promising results in the BRUIN clinical trials for both BTK inhibitor-naive and previously treated chronic lymphocytic leukemia patients, reviewing key efficacy and safety data presented at recent hematology conferences.

EP. 7: Application of Pirtobrutinib in R/R CLL: Expert Perspectives

November 5th 2024

Panelists discuss how utilizing pirtobrutinib in clinical practice, focusing on its application in patients who have developed resistance or intolerance to prior BTK inhibitors, as well as in those who have shown resistance to both BTK and BCL-2 inhibitors in chronic lymphocytic leukemia treatment.

EP. 8: Influence of TLS Risk and Patient Preferences on Treatment Selection in Relapsed/Refractory CLL

November 5th 2024

Panelists discuss how they evaluate patients for tumor lysis syndrome (TLS) risk, considering factors such as tumor burden, renal function, and prior therapies, and how this assessment influences their decision between prescribing a non-covalent BTK inhibitor or a venetoclax-based regimen for chronic lymphocytic leukemia treatment.

EP. 9: Navigating treatment strategies for patients with multi-refractory CLL: CAR-T, ASCT, and PI3K Inhibitors

November 12th 2024

Panelists discuss how various additional treatment options for relapsed/refractory chronic lymphocytic leukemia (CLL) are considered, including CAR-T cell therapy, immunomodulatory drugs like lenalidomide, chemoimmunotherapy regimens, and other emerging therapies, highlighting their potential roles in the evolving treatment landscape.

EP. 10: Sequencing and Combination Strategies with Pirtobrutinib and CAR-T Therapy in R/R CLL

November 12th 2024

Panelists discuss how they approach treatment selection for multi-refractory chronic lymphocytic leukemia (CLL) patients, considering factors such as prior therapy responses, patient fitness, and disease characteristics to guide choices among available options, including CAR T-cell therapy, while also addressing the limitations and challenges associated with each treatment modality in their decision-making process.