My Treatment Approach: Interpreting the Latest Data for Breast Cancer

Expert medical oncologists Laura Spring, MD, and Manali Bhave, MD, discuss recent advances in the treatment of HER2-positive and HER2-low breast cancer, present hypothetical patient cases, and discuss their treatment approaches to illustrate how to incorporate recent data into practice.

EP. 1: Clinical Scenario: A 57-Year-Old Woman With Metastatic Breast Cancer

February 29th 2024

Two oncologists present the clinical scenario of a 57-year-old woman with metastatic HER2-positive breast cancer to discuss their approach for incorporating recent research into clinical decision making around systemic therapy.

EP. 2: Current First-Line Systemic Therapy Options for HER2+ Metastatic Breast Cancer

February 29th 2024

Experts discuss considerations around first-line treatment selection for HER2-positive metastatic breast cancer, including when to diverge from the standard-of-care treatment, as well as the role of brain MRIs at diagnosis.

EP. 3: Key Clinical Trials in the First-Line Treatment of HER2+ Metastatic Breast Cancer

March 7th 2024

Oncologists discuss key learnings from clinical trials investigating the first-line treatment of patients with HER2-positive metastatic breast cancer, and how these findings help inform their clinical practice regarding selection of optimal systemic therapy regimens.

EP. 4: Standard of Care Regimens for Second-Line Treatment of HER2+ Metastatic Breast Cancer

March 7th 2024

Laura Spring, MD, and Manali Bhave, MD, discuss findings from the DESTINY-Breast03 trial and how these results have led them to adopt T-DM1 as the new standard of care over lapatinib/capecitabine for second-line treatment of HER2-positive metastatic breast cancer after progression on first-line trastuzumab and a taxane.

EP. 5: Sequencing Therapies in the Third-Line and Beyond for Patients With HER2+ Metastatic Breast Cancer

March 14th 2024

Doctors Laura Spring and Manali Bhave discuss summarize their recommended sequence of systemic therapy options for HER2-positive metastatic breast cancer, from first-line taxane and dual HER2 blockade through later lines with T-DM1, tucatinib, and other regimens.

EP. 6: Clinical Scenario: A 65-Year-Old Post-Menopausal Woman With Metastatic Breast Cancer

March 14th 2024

Oncologists present the clinical scenario of a 65-year-old woman with recurrent HR-positive, HER2-low breast cancer, and discuss optimal sequencing of systemic therapies in this setting.

EP. 7: Approaches to Mutation Testing for Patients With HR+/HER2-low mBC and ET-Resistant Disease

March 21st 2024

Laura Spring, MD, and Manali Bhave, MD, discuss considerations for systemic therapy selection in a patient with recurrent hormone receptor-positive, HER2-low breast cancer, including use of plasma and tissue genomic testing and endocrine therapy sequencing based on factors like prior response and ESR1 mutation status.

EP. 8: Factors for Consideration When Choosing Among Options for Patients with ET-resistant ER+/HER2- mBC

March 21st 2024

Oncologists discuss considerations for systemic therapy selection beyond first-line endocrine-based regimens in recurrent hormone receptor-positive, HER2-low metastatic breast cancer, including use of additional endocrine therapy combinations, chemotherapy, and supportive care approaches.

EP. 9: Sequencing Antibody-Drug Conjugates (ADCs) in HR+/HER2-Low Metastatic Breast Cancer

March 28th 2024

Laura Spring, MD, and Manali Bhave, MD, discuss sequencing approved antibody-drug conjugates, T-DM1 and sacituzumab govitecan, for hormone receptor-positive, HER2-low metastatic breast cancer after progression on chemotherapy.

EP. 10: Exciting Data in the Treatment of HER2-low from SABCS 2023

March 28th 2024

Laura Spring, MD, and Manali Bhave, MD, highlight promising new systemic treatment options on the horizon for patients with metastatic breast cancer, including T-DM1 for HER2-low disease, the AKT inhibitor capivasertib, and novel endocrine therapies.