Critical Decision Points When Selecting EGFR-Targeted Therapy for NSCLC

Julia Rotow, MD and Edgardo Santos, MD, FACP,discuss how, when selecting frontline therapy for EGFR-mutated non–small cell lung cancer (NSCLC), key considerations include central nervous system involvement, metastases, and mutational factors like TP53. Shared decision-making prioritizes progression-free survival, toxicity, and convenience. Future therapy sequencing, evolving MARIPOSA data, and novel agents shape treatment strategies while balancing efficacy and tolerability.

EP. 1: Frontline Treatment Options in Metastatic EGFR-Mutated NSCLC

March 17th 2025

Panelists discuss how, when discussing frontline regimens for EGFR-mutated non–small cell lung cancer (NSCLC), the NCCN-recommended options include osimertinib monotherapy for its targeted approach with lower toxicity; amivantamab/lazertinib combination for potentially deeper responses in specific mutations; and osimertinib with platinum-doublet chemotherapy for more aggressive disease requiring enhanced tumor control.

EP. 2: EGFR-Mutated NSCLC Disease Risk Stratification

March 17th 2025

Panelists discuss how disease-related factors like central nervous system (CNS) involvement or specific metastatic sites can guide treatment selection, favoring agents with CNS penetration or targeted efficacy. Mutational factors, such as TP53 comutations, may impact therapy response. Patient-related aspects, including age and comorbidities, influence tolerability and regimen choice.