Bridging the Gaps in Lung Cancer: 6 Month Update Winter Lung Cancer Conference 2025

Benjamin P. Levy, MD, and Misty D. Shields, MD, PhD, discuss Bridging the Gaps in lung cancer, a collection and review of updated data from the Winter Lung Cancer Conference 2025, that was significant to their practice and future implications of data across 6 key areas, including small cell lung cancer, perioperative treatment strategies in non–small cell lung cancer (NSCLC), advancements in unresectable early-stage NSCLC, treatment strategies for EGFR-mutated NSCLC, targeting ALK/ROS1/HER2/NRG1 mutations in NSCLC, and immunotherapy in advanced NSCLC.

EP. 1: Expert Insights on Recent Advancements in LS-SCLC

February 20th 2025

Panelists discuss how the ADRIATIC regimen integrates immunotherapy post-chemoradiation in late-stage small cell lung cancer (LS-SCLC). In patients with paraneoplastic syndromes or immune disorders, immunotherapy requires caution. Prophylactic cranial irradiation (PCI) is considered for high-risk cases, while MRI surveillance is preferred for select patients to reduce neurotoxicity.

EP. 2: Key Updates in the Treatment of ES-SCLC

February 20th 2025

Panelists discuss how recent real-world data comparing atezolizumab and durvalumab in extensive-stage non–small cell lung cancer (ES-NSCLC) informs treatment selection, though direct comparisons remain limited. Lurbinectedin is a key second-line option, with emerging combination strategies.