ESMO Congress | Conference

Dr. Finn on the Phase III PALOMA-2 Trial in ER+ Breast Cancer

October 11th 2016

Richard S. Finn, MD, associate professor of Medicine at the UCLA David Geffen School of Medicine, discusses the phase III PALOMA-2 trial during an interview at the 2016 ESMO Congress.

Dr. Scagliotti on the Phase III ASCEND-5 Study in ALK+ NSCLC

October 11th 2016

Giorgio Scagliotti, MD, PhD, professor of Medical Oncology, University of Torino, discusses the design and the results of the phase III ASCEND-5 study during an interview at the 2016 ESMO Congress.

Adding PD-1 Inhibition to Chemotherapy Boosts Response in Untreated NSCLC

October 11th 2016

The addition of pembrolizumab (Keytruda) to frontline platinum-based chemotherapy for advanced non–small cell lung cancer almost doubled the response rate compared with chemotherapy alone.

Fulvestrant Bests Anastrozole in Phase III Breast Cancer Study

October 11th 2016

First-line treatment with fulvestrant led to significantly better progression-free survival compared with anastrozole for patients with HR-positive advanced breast cancer.

Frontline Cabozantinib Bests Sunitinib in mRCC

October 11th 2016

Cabozantinib (Cabometyx) reduced the risk of progression or death by 31% compared with sunitinib (Sutent) in the frontline setting for patients with metastatic renal cell carcinoma.

First-Line Pembrolizumab Shows Substantial Activity in Advanced Bladder Cancer

October 10th 2016

Early results from a pre-planned interim analysis in the KEYNOTE-052 phase II trial of first-line pembrolizumab in cisplatin-ineligible patients with metastatic urothelial cancer demonstrated antitumor activity and a favorable response rate.

Nivolumab Misses PFS Endpoint in First-Line Advanced NSCLC

October 10th 2016

First-line therapy with nivolumab failed to improve progression-free survival in PD-L1 positive non-small cell lung cancer compared with standard chemotherapy.

Unexpected Benefit Observed From Neoadjuvant Therapy in High-Risk Soft Tissue Sarcoma

October 10th 2016

A technically negative trial in high-risk adult soft tissue sarcoma nonetheless produced a significant survival benefit for anthracycline-based neoadjuvant chemotherapy.

Adjuvant Sunitinib Extends DFS in High-Risk RCC

October 10th 2016

Adjuvant sunitinib prolonged disease-free survival by 1.2 years compared with placebo following nephrectomy for patients with high-risk clear cell renal cell carcinoma.

Atezolizumab Significantly Extends Survival in NSCLC

October 10th 2016

Atezolizumab (Tecentriq) reduced the risk of death by 27% compared with docetaxel in patients with advanced non–small cell lung cancer following the failure of platinum-based chemotherapy.

Ceritinib Establishes PFS Advantage in Second-Line ALK+ NSCLC

October 9th 2016

Progression-free survival was more than 3 times longer with ceritinib (Zykadia) than with chemotherapy, the current second-line standard, in patients with advanced ALK-positive non–small cell lung cancer who progressed after first-line crizotinib.

Second-Line Nivolumab Data in mUC Show Efficacy as FDA Considers Approval

October 9th 2016

Safety, efficacy, and biomarker results from the phase II CheckMate-275 trial of the PD-1 inhibitor nivolumab (Opdivo) that support FDA and European Medicines Agency applications were reported at the 2016 ESMO Congress.

Dr. Mirza on the Phase III NOVA Trial in Ovarian Cancer

October 9th 2016

Mansoor Raza Mirza, MD, chief oncologist, Rigshospitalet, Copenhagen University Hospital, discusses the results of the phase III NOVA trial during an interview at the 2016 ESMO Congress.

Dr. Braghiroli on Clinical Characteristics of NRAS-Mutant CRC

October 9th 2016

Maria Ignez Braghiroli, MD, medical oncologist, Instituto do Câncer do Estado de São Paulo, discusses clinical characteristics and outcomes of patients with NRAS-mutant metastatic colorectal cancer (mCRC) during an interview at the 2016 ESMO Congress.

Frontline Pembrolizumab Data Is Practice Changing for NSCLC

October 9th 2016

Single-agent pembrolizumab improved overall and progression-free survival compared with doublet chemotherapy for untreated patients with advanced non–small cell lung cancer who expressed PD-L1 on ≥50% of cells.

Antibody-Drug Conjugate Active in Pretreated Ovarian Cancer

October 9th 2016

A fourth of patients with heavily pretreated advanced ovarian cancer achieved objective responses with novel antibody-drug conjugate targeting protein tyrosine kinase 7.

Dr. Robert on the Phase III COMBI-v Study in BRAF-Mutant Melanoma

October 8th 2016

Caroline Robert, MD, PhD, Head of Dermatology, Institute Gustave-Roussy, discusses the results of the phase III COMBI-v study in BRAF-mutant melanoma during an interview at the ESMO 2016 Congress.

Dr. Bruix on the Phase III RESORCE Trial in HCC

October 8th 2016

Jordi Bruix, MD, head of the Barcelona Clinic Liver Cancer at University of Barcelona, discusses the results of the phase III RESORCE trial in hepatocellular carcinoma (HCC) during an interview at the 2016 ESMO Congress.

Regorafenib Shows Clinical Benefit in Patients with HCC Who Progress on Sorafenib

October 8th 2016

The oral multikinase inhibitor regorafenib (Stivarga) has the potential to become the standard of care as second-line treatment in patients with previously treated hepatocellular carcinoma who are unsuitable for loco-regional therapy and have progressed on sorafenib.

Ribociclib Leads to Major PFS Increase in HR+ Metastatic Breast Cancer

October 8th 2016

Postmenopausal women with hormone receptor-positive metastatic breast cancer had significant slowing of disease progression with the addition of the investigational cyclin-dependent kinase 4/6 inhibitor ribociclib to endocrine therapy.