Sarcomas | Specialty

The OncLive Sarcomas/TGCT condition center page is a comprehensive resource for clinical news and expert insights on tenosynovial giant cell tumor (TGCT), soft tissue sarcoma, gastrointestinal stromal tumor, Ewing sarcoma, and more. This page features news articles, interviews in written and video format, and podcasts that focus on unmet needs, treatment advances, and ongoing research in sarcomas and TGCT.

Moving the Needle in Undifferentiated Pleomorphic Sarcoma: Conclusions

April 20th 2025

In this episode, experts highlight the key takeaways from the Stand Up to Cancer SARC 032 study and its clinical implications.

Five Under 5: Top Oncology Videos for the Week of 4/13

April 20th 2025

The top 5 OncLive videos of the week cover insights in multiple myeloma, AL amyloidosis, myelofibrosis, breast cancer, and sarcoma.

Moving the Needle in Undifferentiated Pleomorphic Sarcoma: Multidisciplinary Collaboration

April 19th 2025

In this episode, experts discuss the landmark SARC 032 study, highlighting the importance of multidisciplinary collaboration.

Orthopedic Oncology Experts Shape Global Consensus on Chondrosarcoma Management

April 19th 2025

R. Lor Randall, MD, FACS, discusses the importance of orthopedic oncology consensus meetings and the need for agreement about certain surgical practices.

Global Analysis Shows Significant Variability in Sarcoma Clinical Trial Availability

April 18th 2025

High variability in sarcoma clinical trial funding, location, and phase was identified in a global analysis conducted over the past decade.

Moving the Needle in Undifferentiated Pleomorphic Sarcoma: Impact of Immunotherapy on Surgical Planning

April 18th 2025

In this episode, experts discuss the impact of neoadjuvant radiation and immunotherapy on surgical planning in patients with soft tissue sarcomas.

Moving the Needle in Undifferentiated Pleomorphic Sarcoma: Surgical Oncology Goals

April 17th 2025

In this episode, experts shed light on the surgical approach to soft tissue sarcomas.

Dr Randall on the Applicability of Bioengineered Bone Marrow Models for Metastasis Control in Sarcoma

April 17th 2025

R. Lor Randall, MD, FACS, discusses the benefits of a 3-dimensional model of the sarcoma tumor microenvironment for studying metastasis control mechanisms.

Moving the Needle in Undifferentiated Pleomorphic Sarcoma: Radiation Oncology and Immune Stimulation

April 16th 2025

In this episode, experts discuss the potential of radiation therapy to enhance immune response in soft tissue sarcomas.

Dr Randall on the Value of Collaborating With Biomedical Engineers to Develop Preclinical Sarcoma Models

April 16th 2025

R. Lor Randall, MD, FACS, discusses the value of collaboration between oncologists and biomedical engineers to develop preclinical sarcoma models.

Moving the Needle in Undifferentiated Pleomorphic Sarcoma: Trial Design and Key Data

April 15th 2025

In this episode, experts discuss the rationale behind the combined treatment in the Stand Up to Cancer SARC 032 trial.

Moving the Needle in Undifferentiated Pleomorphic Sarcoma: Overview of Paradigm

April 14th 2025

In this episode, experts discuss the latest advancements in the multimodal treatment of undifferentiated pleomorphic sarcoma of the extremities.

FDA Grants Fast Track Designation to Emactuzumab for Unresectable TGCT

April 14th 2025

The FDA granted fast track designation to emactuzumab for unresectable tenosynovial giant cell tumor.

Dr Somaiah on Overcoming Challenges to Multidisciplinary Approaches in Sarcoma

April 11th 2025

Neeta Somaiah, MD, details challenges that are associated with pathology diagnosis, NGS, and early opinions for patients with sarcomas.

Intravenous Sirolimus Shows Tolerability, Early Efficacy in Malignant PEComa

April 9th 2025

Phase 1b data support further exploration of intravenous sirolimus in patients with malignant PEComa.

Dr Randall on How Mouse Models Provide Valuable Insights in Preclinical Sarcoma Research

April 7th 2025

R. Lor Randall, MD, FACS, discusses how immunodeficient mouse models support mechanistic and therapeutic discovery in rare sarcoma subtypes.

Dr Randall on Survey Results for Frozen Margin Sampling in Soft Tissue Sarcoma Resection

April 2nd 2025

Frozen section analysis may be better reserved for high-risk tumor resections, as routine use shows limited benefit and increases cost, survey suggests.

Denosumab Biosimilars Earn Positive CHMP Opinion for Osteoporosis and Cancer-Related Bone Disease

April 2nd 2025

The EMA’s CHMP has issued a positive opinion for the denosumab biosimilars Osvyrti and Jubereq for the same indications as the reference products.

Nirogacestat Provides Long-Term Benefits in Desmoid Tumors

March 27th 2025

Nirogacestat sustained long-term efficacy with acceptable safety in patients with desmoid tumors treated in the phase 3 DeFi trial.

Elective Discontinuation May Be Possible With Larotrectinib in TRK Fusion–Positive Sarcomas

March 27th 2025

Pediatric patients with TRK fusion–positive sarcomas may be able to safely discontinue larotrectinib and resume treatment if needed without sacrificing response.