Myeloproliferative Neoplasms | Specialty

The OncLive Myeloproliferative Neoplasms condition center is a comprehensive resource for clinical news and expert insights on myeloproliferative neoplasms, including myelofibrosis, polycythemia vera, and essential thrombocythemia. This page features news articles, interviews in written and video format, and podcasts that focus on unmet needs, treatment advances, and ongoing research in myeloproliferative neoplasms.

Monitoring Strategies in Myelofibrosis

April 12th 2023

Shared insights on monitoring strategies for myelofibrosis, including important considerations for patients receiving treatment with JAK inhibitors.

JAK Inhibitors in Myelofibrosis

April 12th 2023

Panel experts briefly review supporting data for the use of JAK inhibitors in myelofibrosis and discuss the impact of emerging data on the current treatment landscape.

Adding Patient-Specific Comorbidities May Improve Risk Evaluation in Myelofibrosis

April 11th 2023

Adding patient-specific comorbidities improved the prognostic effect of risk prediction models for patients with primary or secondary myelofibrosis, according to findings from an assessment of data collected in Vanderbilt’s Synthetic Derivative and BioVU Biobank comprehensive electronic health record.

Dr Jain on the Use of Haploidentical Donors in Myelofibrosis

April 6th 2023

Tania Jain, MBBS, discusses the use of haploidentical donors in myelofibrosis.

Transplant Therapy in Myelofibrosis

April 5th 2023

Expert perspectives on how to identify and assess patients with myelofibrosis for transplant therapy.

Myelofibrosis: Diagnosis and Prognostic Risk Assessment

April 5th 2023

Comprehensive discussion highlighting diagnostic and molecular testing involved in the diagnosis of myelofibrosis, challenges related to early diagnosis, and consideration factors for assessing prognostic risk.

Imetelstat Displays Early Efficacy in Myelofibrosis; Phase 3 Trial Is Underway

April 4th 2023

The first-in-class telomerase inhibitor imetelstat is poised to expand the myelofibrosis treatment armamentarium should it prove safe and effective in the newly initiated phase 3 IMpactMF trial.

Rusfertide Improves Responses, Meets Primary End Point of REVIVE Trial in Polycythemia Vera

April 3rd 2023

Treatment with rusfertide led to a higher response rate of 69.2% vs 18.5% with placebo in patients with polycythemia vera, meeting the primary end point of the phase 2 REVIVE trial.

Myelofibrosis: Classification, Risk Factors, and Biomarkers

March 29th 2023

Shared insight on classification, risk factors, and important biomarkers and pathways in myelofibrosis.

Polycythemia Vera: Prognosis and Risk for Progression to Myelofibrosis

March 29th 2023

Panel experts share insight regarding prognosis for patients with polycythemia vera and the associated risk for progression to myelofibrosis.

FDA Issues Complete Response Letter for Ruxolitinib Extended-Release Tablets in MPNs

March 24th 2023

The FDA has issued a complete response letter for ruxolitinib extended-release tablets for use once daily in the treatment of patients with certain types of myelofibrosis, polycythemia vera, and graft-vs-host disease.

Emerging Data Offer Alternatives for Patients With Lower-Risk MDS

March 23rd 2023

Frontline treatments that achieve transfusion independence are of paramount importance for patients with lower-risk myelodysplastic syndrome.

Systemic Treatment Options for Polycythemia Vera

March 22nd 2023

A review of systemic treatment options used in polycythemia vera and the roles these play in the current treatment landscape.

Overview of MPNs

March 22nd 2023

A brief overview of myeloproliferative neoplasms and the associated signs and symptoms commonly presenting in patients.

Dr. Rampal on the Role of JAK Inhibitors in Myelofibrosis

March 14th 2023

Raajit K. Rampal, MD, PhD, discusses how the role of JAK inhibitors will continue to evolve in the treatment of patients with myelofibrosis.

Dr. Mascarenhas on the Benefit of Fedratinib in Myelofibrosis

March 9th 2023

John Mascarenhas, MD, discusses the benefit of fedratinib for patients with myelofibrosis.

COVID-19 Vaccine Efficacy Decreases With Ruxolitinib Use in MPNs

March 9th 2023

Treatment with ruxolitinib impaired antibody responses to complete vaccination with the BNT162b2 SARS-CoV-2 vaccine in patients with myelofibrosis or polycythemia vera.

Dr. Mascarenhas on the Role of Pacritinib in Myelofibrosis

March 8th 2023

John Mascarenhas, MD, discusses the role of pacritinib in patients with myelofibrosis.

Ruxolitinib Demonstrates 6-Month Hematocrit Reduction in Polycythemia Vera

March 8th 2023

Treatment with ruxolitinib significantly reduced hematocrit levels and the number of yearly phlebotomies in patients with polycythemia vera, according to findings from a prespecified futility analysis of the phase 2b RuxoBEAT trial.

Dr. Jain on Unmet Needs in Patients with Myelofibrosis Undergoing Allo-SCT

March 6th 2023

Tania Jain, MBBS, discusses the unmet needs for patients with myelofibrosis who receive an allogeneic stem cell transplant.