Multiple Myeloma | Specialty

The OncLive Multiple Myeloma condition center page is a comprehensive resource for clinical news and expert insights on multiple myeloma and how to treat patients with monoclonal antibodies, proteasome inhibitors, bispecific T-cell engagers, immunomodulatory agents, CAR T-cell therapy, and more. This page features news articles, interviews in written and video format, and podcasts that focus on unmet needs, treatment advances, and ongoing research in multiple myeloma.

BCMA Emerges as Hot Target in Myeloma, With CARs Leading the Way

March 5th 2020

Investigators have turned their attention to B-cell maturation antigen, which offers an ideal target for multiple myeloma therapy because of its restricted expression pattern.

Isatuximab Lead Investigator Explains Significance of FDA Approval in Myeloma

March 5th 2020

Paul G. Richardson, MD, discusses the findings from the ICARIA-MM trial and the clinical implications of isatuximab’s FDA approval in multiple myeloma.

Dr. Raje on the Efficacy of Belantamab Mafodotin in Multiple Myeloma

March 5th 2020

Noopur Raje, MD, discusses the utility of belantamab mafodotin in the treatment of patients with multiple myeloma.

Triplets Target Lenalidomide-Refractory Myeloma Subgroup

March 5th 2020

Faith E. Davies, MD, discusses pivotal research in relapsed/refractory myeloma and precision medicine efforts in the field.

Dr. O'Donnell on Unanswered Questions in Multiple Myeloma

March 4th 2020

Betsy O’Donnell, MD, discusses unanswered questions in multiple myeloma.

Novel Combos Thrive in Myeloma, But Challenges Remain

March 3rd 2020

James Weitzman, MD, discusses progress in the multiple myeloma treatment paradigm and what challenges remain.

Penn Investigator Sees Promises and Challenges in Myeloma Target

March 3rd 2020

Adam D. Cohen, MD, discusses the prospects for BCMA-targeting options in multiple myeloma.

Dr. Branagan on Tandem Transplants in Multiple Myeloma

March 3rd 2020

Andrew Branagan, MD, discusses the research tandem transplants in patients with high-risk multiple myeloma.

Dr. Richardson on the FDA Approval of Isatuximab in Relapsed/Refractory Myeloma

March 3rd 2020

Paul G. Richardson, MD, clinical program leader and director of clinical research, Jerome Lipper Multiple Myeloma Center, and institute physician, Dana-Farber Cancer Institute, and RJ Corman Professor of Medicine at Harvard Medical School, discusses the FDA approval of isatuximab-irfc (Sarclisa) for use in combination with pomalidomide (Pomalyst) and dexamethasone in relapsed/refractory multiple myeloma.

Selinexor Regimen Improves PFS in Relapsed/Refractory Myeloma

March 2nd 2020

Selinexor in combination with bortezomib and low-dose dexamethasone led to a statistically significant increase in progression-free survival compared with bortezomib/dexamethasone alone in patients with multiple myeloma who have received 1 to 3 prior lines of therapy.

Pivotal Studies Provide New Path in High-Risk Smoldering Myeloma

March 2nd 2020

The diagnosis and management of smoldering multiple myeloma is an area of tremendous focused research and change over the past decade, with trials yielding intriguing findings that have the potential to change practice.

Next Chapter Begins With CAR T-Cell Therapy in Myeloma

March 1st 2020

Noopur Raje, MD, discusses the investigational CAR T-cell therapies and strategies in the multiple myeloma pipeline.

Dr. Lonial on High-Risk Patients With Smoldering Multiple Myeloma

February 28th 2020

Sagar Lonial, MD, FACP, discusses how the treatment landscape has evolved for patients with smoldering multiple myeloma.

Expert Highlights Advantage of Triplet Therapies in Relapsed/Refractory Myeloma

February 28th 2020

Andrew Yee, MD, reflects on recent clinical trials in multiple myeloma that focused on novel multidrug regimens.

More Research Required to Determine Best Practices in High-Risk Myeloma

February 27th 2020

Andrew Branagan, MD, discusses the evolving role of transplant and ongoing research in high-risk multiple myeloma.

Selinexor Offers Patients New Path in Relapsed/Refractory Myeloma

February 27th 2020

Robb S. Friedman, MD, shares insight on the emergence of selinexor in the treatment paradigm for patients with relapsed/refractory multiple myeloma.

Dr. Kumar on the Role of Stem Cell Mobilization in Multiple Myeloma

February 21st 2020

Shaji K. Kumar, MD, discusses the role of stem cell mobilization in multiple myeloma. This is important in patients with myeloma who are eligible for stem cell transplantation.

The Potential Utility of CLR 131 in Multiple Myeloma

February 19th 2020

Jarrod Longcor, MS, MBA, discusses the potential utility of the small-molecule radiotherapeutic phospholipid-drug conjugate CLR 131 in patients with multiple myeloma.

Dr. Costello on the Future of Isatuximab in Relapsed/Refractory Multiple Myeloma

February 18th 2020

Caitlin Costello, MD, discusses the future of isatuximab in relapsed/refractory multiple myeloma.

Daratumumab Becomes Treatment Staple in Newly Diagnosed Multiple Myeloma

February 14th 2020

The foremost choice in the treatment of patients with newly diagnosed multiple myeloma is determining whether a patient is eligible for transplant, as that choice will set the stage for all future decisions.