Immuno-Oncology | Specialty

Promising Immuno-Oncology Approaches in the Management of Squamous Cell Carcinoma of the Head and Neck

January 27th 2016

Substantial evidence exists that a subset of squamous cell cancers of the head and neck display phenotypic changes that predict activity for immune checkpoint inhibitors.

Vaccine Strategy for Biomarker in NSCLC Reaches Phase III Study

January 27th 2016

An emerging vaccine strategy, of TG4010 immunotherapy and first-line chemotherapy, that could target a potential new biomarker in patients with advanced non-small cell lung cancer (NSCLC) has successfully reached a phase III clinical trial, researchers noted.

Mismatch Repair-Deficient GI Tumors Respond to Anti—PD-1 Therapy

January 26th 2016

Mismatch repair-deficient gastrointestinal tumors are highly responsive to checkpoint blockade with anti-PD-1 therapy.

Avelumab Clinically Active in Advanced Gastric/GEJ Cancer

January 23rd 2016

The investigational anti–PD-L1 antibody avelumab demonstrated clinical activity as a second-line and maintenance therapy for patients with unresectable gastric or gastroesophageal junction cancer.

FDA Expands Nivolumab's Frontline Melanoma Approval to Include BRAF-Mutant Patients

January 23rd 2016

The FDA has expanded the frontline melanoma indications for nivolumab as a single agent and in combination with ipilimumab to include patients with BRAF mutations.

Nivolumab Shows Clinical Activity in Gastric Cancer

January 22nd 2016

The PD-1 inhibitor nivolumab (Opdivo) had an overall response rate of 14% with an acceptable safety profile in patients with gastric or gastroesophageal junction cancer.

Pembrolizumab Active in Advanced Esophageal Carcinoma

January 22nd 2016

The PD-1 inhibitor pembrolizumab (Keytruda) elicited encouraging activity with mild adverse events as a treatment for patients with advanced PD-L1–positive esophageal carcinoma.

Nivolumab Active in Heavily Pretreated Esophageal Cancer

January 22nd 2016

The immune checkpoint inhibitor nivolumab demonstrated activity in patients with previously treated esophageal cancer.

Radiation/Immunotherapy Combos Slow to Gain Traction, But Have Potential in Prostate Cancer

January 20th 2016

Steven Finkelstein, MD, explains why radiation and immunotherapy may be an effective combination in prostate cancer.

High T-Cell Diversity Linked to Better Prognosis in mRCC

January 14th 2016

The VEGFR inhibitor pazopanib was efficacious independent of T-cell receptor–gamma entropy in metastatic renal cell carcinoma setting.

Emerging Targets in NSCLC Treatment

January 13th 2016

Subtypes in NSCLC: BRAF and RET

January 13th 2016

Approval of Third-Generation TKIs for EGFR-Targeted Therapies

January 13th 2016

Next-Generation ALK Inhibitors for NSCLC

January 13th 2016

Ceritinib in Crizotinib-Resistant NSCLC

January 13th 2016

Crizotinib for ALK-Rearranged NSCLC

January 13th 2016

EGFR Inhibition and Resistance Mechanisms

January 13th 2016

Current Practices in NSCLC Genetic Testing

January 13th 2016

Therapeutic Classes in Advanced NSCLC

January 13th 2016

Experts Grapple With Nuances of Navigating New Frontier in Melanoma

January 13th 2016

Questions remain in terms of how to optimally sequence and/or combine both targeted agents and immunotherapies in melanoma.