Genitourinary Cancers | Specialty

The OncLive Genitourinary Cancer condition center page is a comprehensive resource for clinical news and expert insights across genitourinary (GU) malignancies, including renal cell carcinoma, urothelial carcinoma, and prostate cancer. This section features news articles, interviews in written and video format, and podcasts that focus on the evolving treatment paradigm of GU cancers and emerging research.

Impact of Treatment Selection and Real-World Outcomes in Advanced RCC

December 20th 2023

Brian Rini, MD, discusses the impact of real-world outcomes on treatment selection, highlighting frontline combination axitinib plus pembrolizumab in advanced RCC.

Tackling Toxicity Management in Combination Regimens for Advanced RCC

December 20th 2023

A comprehensive discussion on toxicity management and patient tolerability for combination regimens in the setting of advanced RCC.

ctDNA Could Aid in Treatment Escalation and De-escalation Decisions in Kidney Cancer

December 19th 2023

Alan Tan, MD, discusses how utilizing circulating tumor DNA may provide valuable insight into when to escalate vs de-escalate treatment for patients with renal cell carcinoma.

Non–Clear Cell RCC Subtypes Require Individualized Approach to Treatment Selection

December 19th 2023

Jaime R. Merchán, MD, spotlights case studies of patients with rare non-ccRCC histologies, discussing their clinical presentation, recent data on immunotherapy and targeted treatment options for the management of these disease subtypes, and patient outcomes on these therapies.

Triple Combination Therapies in RCC: Clinical Trial Insights

December 19th 2023

Experts discuss the potential of triple combination therapies for high-risk renal cell carcinoma (RCC) patients and the challenges posed by their toxicity profiles, emphasizing the need for compelling clinical trial data.

RCC Research May Lead to SOC Improvements and Individualized Treatment Plans

December 15th 2023

Marijo Bilusic, MD, PhD, highlights key insights about renal cell carcinoma that were presented at the meeting covering considerations on sequencing TKIs, the need for further research to elucidate novel therapies, and the importance of offering clinical trials to all patients with genitourinary malignancies.

Enfortumab Vedotin and the Role of ADCs in Bladder Cancer

December 15th 2023

Bladder cancer specialists discuss enfortumab vedotin and the role of antibody-drug conjugates in the treatment landscape.

Bladder Cancer: Highlights from ESMO 2023 and Ongoing Developments

December 15th 2023

The expert panel reviews highlights from ESMO 2023 and discusses ongoing developments in the treatment landscape for bladder cancer.

FDA Approves Belzutifan for Advanced Renal Cell Carcinoma

December 14th 2023

The FDA has approved belzutifan (Welireg) for the treatment of patients with advanced renal cell carcinoma (RCC) following a PD-1 or PD-L1 inhibitor and a VEGF TKI.

Frontline IO/TKI Regimens Continue to Evolve in ccRCC

December 14th 2023

Jaime R. Merchán, MD, discusses the evolution and current role of IO/TKI regimens in advanced RCC; highlights data from the phase 3 CLEAR and KEYNOTE-426 trials supporting the use of pembrolizumab-based regimens in untreated ccRCC; and speculates on how future biomarker-driven research could improve the benefit seen with these combinations in this disease.

CLEAR Trial: Lenvatinib plus Pembrolizumab in Advanced RCC

December 13th 2023

Experts highlight key clinical updates from the CLEAR trial presented at the 2023 IKCS: North America congress, assessing lenvatinib plus pembrolizumab in patients with advanced RCC.

The Evolution of Advanced Renal Cell Carcinoma

December 13th 2023

Brian Rini, MD, and Hans Hammers, MD, PhD, discuss the evolution of management for advanced renal cell carcinoma (RCC), noting the role of biomarkers and its use in practice.

Novel Therapies for Advanced RCC: LITESPARK-005 and Treatment Sequencing

December 12th 2023

Leading oncologists discuss advanced treatment options for patients with progressing renal cell carcinoma (RCC), focusing on the promising results from LITESPARK-005 and treatment sequencing strategies.

Navigating Toxicity Discussions With Patients With Renal Cell Carcinoma

December 12th 2023

Expert insight into how to discuss and manage treatment-related toxicities with cancer patients and their families, emphasizing the importance of early communication and vigilance.

State of Science Summit- Genitourinary Cancer: Chaired by Petros Grivas, MD, PhD, and Evan Y. Yu, MD

December 12th 2023

State of Science Summit- Genitourinary Cancer: Chaired by Petros Grivas, MD, PhD, and Evan Y. Yu, MD

Bladder Cancer: Treatment Options and Managing Adverse Effects

December 7th 2023

Comprehensive insights on treatment considerations and managing immunotherapy-related adverse effects for patients with bladder cancer.

Monitoring Patients With NMIBC

December 7th 2023

The panel discusses strategies for monitoring patients with non–muscle invasive bladder cancer and the potential role of biomarkers.

Sequencing and Second-Line Therapy in RCC: Patient Scenario

December 5th 2023

Expert oncologists discuss the challenges and considerations in choosing second-line therapy for a patient with metastatic renal cell carcinoma (RCC) in a case-based context.

Dr Maksimovic on a Novel Preclinical Model of Bone Metastasis in ccRCC

December 5th 2023

Stefan Maksimovic, MD, discusses the preclinical investigation of innovative tissue engineering with optical windows, state-of-the-art fluorescence reporter technology, and intravital multiphoton microscopy in mouse models with clear cell renal cell carcinoma.

TKI and Immunotherapy Combo Efforts in RCC Remain of Interest as Treatment Arsenal Evolves

December 4th 2023

Final outcomes from the phase 1b/2 Study 111/KEYNOTE-146 trial, evaluating treatment with lenvatinib and pembrolizumab in patients with advanced renal cell carcinoma, has sparked interest in the use of this combination.