Colorectal Cancer | Specialty

HER2 Amplification Shows Prognostic Capabilities in mCRC

August 22nd 2023

HER2 amplification appears to be prognostic in patients with RAS wild-type metastatic colorectal cancer but may not be predictive of survival benefit as a first-line treatment option in combination with panitumumab vs standard-of-care bevacizumab.

Recent Updates in Early Onset Colorectal Cancer: What We Know and Where to Go

August 22nd 2023

Oncologists globally explore trends, challenges in diagnosis, and future directions in patients with colorectal cancer.

Dr Fakih on the BASECAMP-1 Study in HLA-A*0201-Positive Solid Tumors

August 21st 2023

Marwan G. Fakih, MD, discusses the main objective and design of the observational BASECAMP-1 study and how it functions alongside the phase 1/2 EVEREST-1 study in patients with solid tumors.

Avelumab Increases PFS Rates in dMMR/MSI Metastatic CRC

August 18th 2023

Patients with mismatch repair–deficient and/or microsatellite instability metastatic colorectal cancer experienced a progression-free survival benefit with longer disease control following treatment with avelumab compared with standard second-line chemotherapy.

Dr Kopetz on the Investigation of Encorafenib, Cetuximab, and Chemotherapy in mCRC

August 16th 2023

Scott Kopetz, MD, PhD, FACP, discusses the phase 3 BREAKWATER trial in patients with BRAF V600E–mutant metastatic colorectal cancer.

FDA Grants Breakthrough Device Designation to HLA-LOH Companion Diagnostic Test

August 16th 2023

The FDA has granted a breakthrough device designation to HLA-LOH as a companion diagnostic test, according to an announcement from Tempus.

Franklin on Strategies to Ameliorate the Effect of Social Determinants on CRC Screening Rates

August 16th 2023

Isabelle Franklin, discusses strategies healthcare providers can implement to address or ameliorate disparities in place that are affecting screening rates in colorectal cancer.

Franklin on Future Steps for Investigating the Association Between Social Needs and CRC Screening Rates

August 15th 2023

Isabelle Franklin, discusses future steps to be taken following an investigation into the association between self-reported social needs and colorectal cancer screening rates.

Dr Hitchins on the Association Between Constitutional MLH1 Methylation and MRD in Select Cancers

August 15th 2023

Megan Hitchins, PhD, discusses results from an analysis on the prevalence of high-risk constitutional MLH1 methylation in early-onset colorectal and endometrial cancers displaying mismatch repair deficiency.

BDC-1001 Monotherapy Under Further Evaluation in Phase 2 Trial in HER2+ Cancers

August 11th 2023

The first patients have been dosed in the phase 2 portion of a phase 1/2 trial evaluating BDC-1001 monotherapy in patients with HER2-positive colorectal cancer, endometrial cancer, and gastroesophageal cancer.

Dr Hays on Unmet Needs in CRC

August 10th 2023

John L. Hays, MD, PhD, discusses unmet needs for patients with colorectal cancer and future directions for research in this disease.

Dr Bloomer on the Rationale for the ColoCare Study in Newly Diagnosed CRC

August 4th 2023

Amanda Bloomer, PhD, discusses the rationale for launching the ColoCare study, an investigation into the health-related quality of life outcomes of younger vs older adult patients with newly diagnosed colorectal cancer.

Time to Treatment Initiation Affected by Demographics, Socioeconomics in Solid Tumors

August 2nd 2023

Delays in time to treatment initiation may be associated with demographic and socioeconomic disparities, with care coordination, clinical, and socioeconomic factors representing potential predictors of TTI, according to findings from a retrospective cohort study published in JCO Oncology Practice.

Dr Taieb on the FDA Approval of TAS-102 Plus Bevacizumab in mCRC

August 2nd 2023

FDA Approves Trifluridine/Tipiracil Plus Bevacizumab in Previously Treated Metastatic Colorectal Cancer

August 2nd 2023

The FDA has approved trifluridine and tipiracil (Lonsurf) plus bevacizumab (Avastin) for patients with metastatic colorectal cancer who were previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy; a VEGF inhibitor; and an EGFR inhibitor, if they have RAS wild-type disease.

Franklin on the Investigation of Social Needs and Screening Rates in CRC

August 1st 2023

Isabelle Franklin, discusses the investigation of the correlation between self-reported social needs and colorectal cancer screening.

ERASur Study Evaluates Total Ablative Therapy Plus Systemic Treatment in mCRC

August 1st 2023

The safety and efficacy of adding total ablative therapy of all disease sites to standard systemic treatment is being investigated in patients with limited metastatic colorectal cancer as part of the ongoing phase 3 ERASur study.

Dr Hitchcock on Potential Clinical Implications of the ERAsur Trial in Limited mCRC

July 31st 2023

Kathryn Hitchcock, MD, PhD, expands on potential clinical implications of the ongoing phase 3 ERAsur trial in metastatic colorectal cancer

Molecular Testing Drives Progress in CRC

July 31st 2023

Emerging strategies leveraging biomarker data for the treatment of patients with early-stage and metastatic colorectal cancer have made precision medicine a top-of-mind topic for gastrointestinal oncologists.

Future Perspectives on HER2+ Metastatic Colorectal Cancer

July 28th 2023

Tanios S. Bekaii-Saab, MD, offers closing thoughts on the unmet needs and future of HER2+ metastatic colorectal cancer treatment.