Chronic Lymphocytic Leukemia | Specialty

The OncLive Chronic Lymphocytic Leukemia condition center page is a comprehensive resource for clinical news and expert insights on treatment advances and ongoing research in chronic lymphocytic leukemia. This page features news articles, interviews in written and video format, and podcasts that focus on unmet needs and updates with chronic lymphocytic leukemia therapy.

Ublituximab/Umbralisib Outperforms Chemoimmunotherapy in Patients with CLL

December 7th 2020

December 7, 2020 — The combination of ublituximab and umbralisib, 2 novel compounds targeting CD20 and PI3Kδ, respectively, has shown synergistic activity in patients with chronic lymphocytic leukemia compared with standard of care chemoimmunotherapy irrespective of prior treatment.

Dr. Wierda on the Results of the CAPTIVATE Trial in CLL and SLL

December 5th 2020

William G. Wierda, MD, PhD, discusses results from the CAPTIVATE trial in chronic lymphocytic leukemia and small lymphocytic lymphoma.

Survival Benefit of Venetoclax and Rituximab in Relapsed/Refractory CLL Persists Out to Five Years

December 5th 2020

December 5, 2020 - Patients with relapsed or refractory chronic lymphocytic leukemia treated with venetoclax and rituximab had a sustained progression-free survival and overall survival benefit at five years compared with those treated with bendamustine and rituximab.

Continued Ibrutinib, Post Fixed-Duration of Ibrutinib/Venetoclax, Elicits Similar 1-Year DFS Vs Placebo in CLL/SLL

December 5th 2020

December 5, 2020 - Patients with previously untreated chronic lymphocytic leukemia /small lymphocytic lymphoma who received a placebo following a fixed-treatment duration of ibrutinib combined with venetoclax achieved similar 1-year disease-free survival results compared with patients who remained on ibrutinib following confirmed undetectable minimal residual disease.

Dr. Seymour on Investigational BTK Inhibitors in CLL

December 4th 2020

Erlene Seymour, MD, discusses investigational BTK inhibitors in chronic lymphocytic leukemia.

Evolving Data for CLL Set Stage for Frontline Therapy

December 4th 2020

In a recent OncLive Peer Exchange®, a panel of hematologic experts discusses the paradigm shift in frontline therapy options for patients with CLL.

Treatment Considerations in Newly Diagnosed CLL

December 4th 2020

Drs Stilgenbauer and Ghia provide insight on initial treatment considerations for patients with newly diagnosed chronic lymphocytic leukemia.

Dr. Winter on Emerging Agents in CLL

December 3rd 2020

Allison Winter, MD, discusses emerging agents in chronic lymphocytic leukemia.

Dr. Ayers on the Evolving Treatment Landscape in CLL

December 2nd 2020

Emily C. Ayers, MD, hematologist/oncologist, assistant professor, University of Virginia Health, discusses the evolving treatment landscape in chronic lymphocytic leukemia.

FDA Approval Sought for Ublituximab/Umbralisib Combo in CLL

December 1st 2020

December 1, 2020 - A rolling submission of a biologics license application to the FDA has been initiated for the CD20-directed monoclonal antibody ublituximab in combination with the PI3K-delta and CK1-epsilon inhibitor umbralisib for the treatment of patients with chronic lymphocytic leukemia.

Dr. Winter on the Role of Frontline Targeted Therapies in CLL

November 30th 2020

Allison Winter, MD, hematologist/medical oncologist, Cleveland Clinic, discusses the role of frontline targeted therapies in chronic lymphocytic leukemia.

Panelists Parse Out Answers to Key Questions in Hematologic Malignancies

November 25th 2020

Stephen A. Strickland, MD, BS, MS, MSCI, relays insightful questions from the audience to the speakers, who provided insight into how they are navigating the evolving treatment landscape of hematologic malignancies.

Dr. Ayers on Trials Examining Venetoclax in CLL

November 24th 2020

Emily C. Ayers, MD, discusses recent trials examining the use of venetoclax in patients with chronic lymphocytic leukemia.

Dr. Ayers on Recent Developments in CLL

November 19th 2020

Emily C. Ayers, MD, discusses recent developments in chronic lymphocytic leukemia.

Dr. Winter on the Utility of PI3K Inhibitors in CLL

November 18th 2020

Allison Winter, MD, discusses the utility of PI3K inhibitors in chronic lymphocytic leukemia.

BTK Inhibitor Combos Could Transform the Complex CLL Armamentarium

November 18th 2020

Alan P. Z. Skarbnik, MD, breaks down factors that should be kept in mind when navigating the complex chronic lymphocytic leukemia armamentarium as it relates to BTK inhibitors.

Dr. Awan on the Importance of Risk Stratification in CLL

November 17th 2020

Farrukh Awan, MD, discusses the importance of risk stratification in chronic lymphocytic leukemia.

Novel Agents Capture Attention in Newly Diagnosed CLL/SLL

November 17th 2020

Matthew Lunning, DO, discussed other key considerations for choosing treatments, continuous vs fixed-duration therapies, and emerging agents for patients with relapsed/ refractory CLL and SLL.

Dr. Ayers on Unmet Needs in CLL

November 16th 2020

Emily C. Ayers, MD, discusses unmet needs in chronic lymphocytic leukemia.

Dr. Danilov on the Role of Disease Biology in Up-front Treatment Selection in CLL

November 10th 2020

Alexey V. Danilov, MD, PhD, discusses the role of disease biology in up-front treatment selection in chronic lymphocytic leukemia.