CAR T-cell Therapy | Specialty

The OncLive CAR T-cell therapy condition center page is a comprehensive resource for clinical news and expert insights on FDA-approved and investigational CAR T-cell products in hematologic malignancies, specifically acute lymphoblastic leukemia, non-Hodgkin lymphoma, and multiple myeloma. CAR T-cell research in solid tumors is also under exploration. This page features news articles, interviews in written and video format, and podcasts that focus on updates with CAR T-cell therapy and the ongoing research with this type of treatment.

Real-World Data and CAR T Therapy

December 23rd 2019

CAR-T Therapy Treatment Variables

December 23rd 2019

High-Risk Lymphoma: The ZUMA-1 and SCHOLAR-1 Trials

December 23rd 2019

Adult ALL and Data from ZUMA-3

December 23rd 2019

CAR T-Cell Therapy: Relapsed/Refractory ALL

December 23rd 2019

Treating Common Toxicities From CAR T Therapy

December 23rd 2019

A Conversation on MRD in ALL

December 23rd 2019

CAR T-Cell Therapy in Pediatric ALL

December 23rd 2019

Understanding of MRD and CAR T-Cell Therapy in ALL Continues to Evolve

December 23rd 2019

Minimal residual disease has become an important investigational prognostic marker and risk stratification tool in acute lymphoblastic leukemia.

Exploration With Blinatumomab and CAR T-Cell Therapy Continues in ALL

December 22nd 2019

Joseph Wynne, MD, discusses ongoing studies with blinatumomab and CAR T-cell therapy in acute lymphoblastic leukemia, as well as the importance of assessing minimal residual disease in this space.

Real-World Analysis Shows Cost-Reducing Benefit With CAR-T in Relapsed DLBCL

December 20th 2019

Karl M. Kilgore, PhD, discusses how results of real-world analysis may impact the utilization of CAR T-cell therapy for older patients with relapsed/refractory diffuse large B-cell lymphoma.

FDA Approval Sought for Liso-Cel in Large B-Cell Lymphoma

December 19th 2019

Bristol-Myers Squibb has submitted a biologics license application to the FDA seeking approval of the anti-CD19 CAR T-cell therapy lisocabtagene maraleucel for the treatment of adult patients with relapsed/refractory large B-cell lymphoma after at least 2 prior therapies.

Dr. Park on Potential Alternate CAR T-Cell Targets in B-Cell Malignancies

December 14th 2019

Jae H.Park, MD, discusses potential alternate CAR T-cell targets in B-cell malignancies.

Characteristics, Healthcare Utilization, and Costs of Medicare Patients Receiving CAR T-Cell Therapy

December 13th 2019

Karl M. Kilgore, PhD, senior research scientist, Avalere Health, discusses real-world data regarding Medicare patients with non-Hodgkin lymphoma receiving CAR T-cell therapy.

Updated bb21217 Data Continue to Impress in Multiple Myeloma

December 11th 2019

The CAR T cell therapy bb21217 demonstrated high very good partial response or better rates in patients with heavily pretreated relapsed/refractory multiple myeloma.

Dr. Perales on the Future of CAR T-Cell Therapy in DLBCL and Follicular Lymphoma

December 10th 2019

Miguel-Angel Perales, MD, discusses the future of CAR T-cell therapy in diffuse large B-cell lymphoma and follicular lymphoma.

Dr. Madduri on the Results of the CARTITUDE-1 Trial in Multiple Myeloma

December 9th 2019

Deepu Madduri, MD, assistant professor, medicine, hematology and medical oncology, Mount Sinai Hospital, discusses the results of the phase Ib/II CARTITUDE-1 trial of the BCMA-directed CAR T-cell therapy JNJ-4528 in patients with heavily pretreated relapsed/refractory multiple myeloma.

Early Steroid Use Reduces Risk of Cytokine Release Syndrome With Axi-Cel

December 9th 2019

Steroid use while cytokine release syndrome and neurologic toxicities are at grade 1, instead of waiting until grade 3, reduces the rate of CAR T-cell treatment–related CRS and neurologic events.

Dr. Abramson on Safety and Efficacy of Liso-Cel in Relapsed/Refractory Large B-Cell Lymphoma

December 9th 2019

Jeremy S. Abramson, MD, clinical director, Center for Lymphoma, Massachusetts General Hospital, discusses the pivotal safety and efficacy results from phase I TRANSCEND NHL 001 trial of lisocabtagene maraleucel (liso-cel) in patients with relapsed/refractory large B-cell lymphoma.

Liso-Cel Induces High Rate of Durable Responses in LBCL

December 9th 2019

CD19-directed CAR T-cell therapy induced a high rate of rapid and durable complete responses in patients with aggressive relapsed/refractory large B-cell lymphoma.