Precision Medicine in Oncology® | Specialty

The OncLive Precision Medicine in Oncology® condition center page is a comprehensive resource for clinical news and expert insights on precision-focused approaches in patients with cancer, with gene-targeted tyrosine kinase inhibitors and antibody-drug conjugates, checkpoint inhibitors, tumor-infiltrating lymphocyte therapy, and other tailored treatments. This page features news articles, interviews in written and video format, and podcasts that focus on updates and ongoing research with personalized therapies across solid and hematologic tumors.

PARP Inhibitor Meets Goals in Phase II Ovarian Cancer Trial

June 23rd 2014

One-quarter of patients with relapsed or refractory BRCA-mutant ovarian cancer attained major objective responses to treatment with the investigational PARP inhibitor veliparib.

Dr. Sequist Discusses the Efficacy of CO-1686 for NSCLC

June 23rd 2014

Lecia V. Sequist, MD, medical oncologist, associate professor, Massachusetts General Hospital, Harvard Medical School, discusses the efficacy of CO-1686 for the treatment of non-small cell lung cancer.

Why Chemotherapy Remains Vital in an Era of Targeted Agents and Immunotherapies

June 20th 2014

When Franco Muggia, MD, was a freshly minted oncologist 50 years ago, his new colleagues warned him not to waste much time learning about a drug like fluorouracil.

Conclusion: Improving Outcomes in Melanoma

June 17th 2014

Surgery Following Systemic Therapy in Melanoma

June 17th 2014

Nivolumab Plus Ipilimumab in Advanced Melanoma

June 17th 2014

Immunotherapy Combinations in Advanced Melanoma

June 17th 2014

Novel Therapies in Metastatic Melanoma

June 17th 2014

Strategies for the Detection of Recurrent Melanoma

June 17th 2014

Ipilimumab Side Effect Management in Melanoma

June 17th 2014

Adjuvant Treatment Selection in High-Risk Melanoma

June 17th 2014

Adjuvant Therapy for Stage III Melanoma

June 17th 2014

Role of Adjuvant Radiation Therapy in Melanoma

June 17th 2014

Molecular Testing in Resectable Melanoma

June 17th 2014

Lymph Node Management in Melanoma

June 17th 2014

Imaging and SLN Biopsy for Patients With Melanoma

June 17th 2014

Introduction: Surgical Excision of Melanoma

June 17th 2014

Leading Genome Researchers Confident That the Cancer Puzzle Will Be Solved

June 17th 2014

Gad Getz, PhD, MSc, focuses on cancer genome analysis, particularly cataloging all of the genomic events that occur during the development of cancer, in his laboratory at the Broad Institute at MIT and Harvard.

Dr. Kim Discusses Detecting EGFR and KRAS Mutations from Cell-Free Plasma DNA of NSCLC Patients

June 16th 2014

Edward S. Kim, MD, chairman, Solid Tumor Oncology and Investigational Therapeutics, Levine Cancer Institute, Carolinas HealthCare System, discusses the use of improved and complete enrichment co-amplification at lower denaturation temperature method for the detection of EGFR and KRAS mutations from cell-free plasma DNA of patients with non-small cell lung cancer (NSCLC).

Targeted Therapy Challenges:More Cancer Genes Discovered, Mutational Burdens Defined

June 13th 2014

Even as technological advances make it possible to sequence DNA on a large scale at relatively lower costs and in shorter time-frames, emerging evidence from the world's top research laboratories suggests that scientists are still a long way from having a complete catalog of cancer genes.