William Oh, MD, chief, Division of Hematology and Medical Oncology, professor of medicine and urology, Mount Sinai School of Medicine, discusses the management of patients with hormone-sensitive prostate cancer.

One of the biggest developments for the treatment of patients with advanced prostate cancer has been the management of metastatic hormone-sensitive prostate cancer, says Oh. The CHAARTED trial compared androgen deprivation therapy (ADT) versus ADT plus 6 cycles of docetaxel. This study favored the early use of chemotherapy, while the STAMPEDE trial further confirmed those findings.

The LATITUDE trial investigated ADT plus or minus abiraterone (Zytiga) and showed a comparable benefit of up to 2 to 3 years of abiraterone plus prednisone in the treatment of hormone-sensitive prostate cancer.

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Dr. Oh on the Management of Hormone-Sensitive Prostate Cancer

William Oh, MD, professor, Mount Sinai Hospital, discusses the results from a trial that compared second-line chemotherapy to alternative androgen receptor-targeted agents (ARTA) in patients with metastatic castration-resistant prostate cancer (mCRPC).

In this study, 345 patients who showed a lack of response to first-line ARTA were enrolled using Altos electronic medical records. Patients received either second-line docetaxel or cabazitaxel, or alternative ARTA.

Oh concludes that treatment with second-line chemotherapy proved more suitable for this patient subset than ARTA.

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William Oh, MD

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