Veda Giri, MD, associate professor, Thomas Jefferson University Hospital, discusses genes that are associated with a risk of developing prostate cancer.

The genes that have had the greatest association of risk for prostate cancer are 

 has been associated with aggressive prostate cancer. 

 is another hereditary prostate cancer gene that doesn’t have a role in guiding management for advanced or metastatic disease, but does seem to confer some of the highest risks for prostate cancer. How to incorporate it into screening is also being studied, says Giri.

 that are linked with Lynch syndrome, a hereditary colon cancer syndrome, can also be very important in terms of considering clinical trials for men with advanced prostate cancer.

Additional genes in the repair pathways are also of importance, particular in men with metastatic disease in terms of guiding their treatment, states Giri. The current NCCN guidelines have expanded beyond 

. Sidney Kimmel Cancer Center at Thomas Jefferson University Hospital hosted a consensus conference in which experts expanded the genetic testing for men with prostate cancer and included genes like 

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Dr. Giri on Genes that Carry a Risk for Prostate Cancer

Veda Giri, MD, associate professor, Thomas Jefferson University Hospital, discusses testing for inherited prostate cancer.

There are few scenarios in which men should consider getting tested for inherited prostate cancer, says Giri. For a man who has had metastatic disease and is progressing after going through the standard lines of therapy, genetics can inform additional options for treatment or clinical trials. There are increasing FDA indications for PARP inhibitors and checkpoint inhibitors for patients with mismatch repair-deficient cancers, says Giri.

Another group of men who may want to consider genetic testing are those who have a family history of cancer. This is not limited to prostate cancer, says Giri, but men who have a family history of breast, ovarian, pancreatic or colon cancer, as these malignancies can be linked to inherited risk for prostate cancer.

Veda Giri, MD, associate professor, Thomas Jefferson University Hospital, discusses testing for inherited prostate cancer.
 

Veda Giri, MD

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Dr. Giri on Genes that Carry a Risk for Prostate Cancer

Dr. Giri Discusses Testing for Inherited Prostate Cancer