University of Florida Health Cancer Center

 has received prestigious designation from the National Cancer Institute, or NCI, and joins the ranks of the country’s most distinguished cancer centers, becoming the 72nd in the United States and the only one in North Central Florida.

The designation signifies that the UF Health Cancer Center has met rigorous standards in its leading-edge cancer research programs, advanced scientific leadership, distinctive training programs and forward-thinking community outreach.

“This is a big deal — and it’s going to make a difference for many of Florida’s families as their loved ones fight cancer,” 

 said. “This designation keeps UF Health and the UF Health Cancer Center on the cutting edge of research and innovation — and ensures top-notch care.”

The center will receive $2.1 million annually from the NCI to enhance its ability to attract more world-class researchers and clinical investigators and train the next generation of the cancer research workforce, while increasing its competitiveness for cancer research grants.

, director of the Cancer Center and the Marshall E. Rinker Sr. Chair in the 

, said the NCI designation — and its ability to boost cancer research funding — means a brighter future for those in this region affected by cancer.

“We envision a future where highly tailored and personalized approaches to cancer prevention, diagnosis and treatment allow us to intercept cancer at earlier stages, offer more effective and less toxic therapies, and provide higher rates of cure,” Licht said.

At a time when Florida has the nation’s second-highest cancer burden, the funding will provide more resources for innovative clinical trials and increase access to cancer care. Being part of the NCI network means patients in North Central Florida and beyond can be assured of access to the most advanced cancer treatments and innovation — backed by research conducted by dedicated scientists.

, created in 1971, is one of the anchors of the nation’s cancer research effort and is an innovation engine for U.S. cancer research progress. The UF Health Cancer Center accelerated its years long effort to achieve designation when Licht became director in fall 2015. Support through the 

, passed in 2014 and initiated by Sen. Rick Scott while governor, was critical, allowing the center to build a critical mass of researchers in its 

. Partnerships with state and federal officials enabled the center to secure integral funding and support for cancer research.

The center doubled its peer-reviewed cancer research funding since 2016, with $48.8 million in total cancer research grants and 359 active cancer research projects last year. The center also doubled patient participation in new cancer treatments via clinical trials. In 2022, 164 clinical trials were available to patients in the center’s 23-county coverage area. Clinical trials give cancer patients access to new treatments while doctors study their efficacy.

Besides expanding research grants and clinical trials, success factors in securing the designation include:

Creating a collaborative environment harnessing all of UF’s brainpower, with 

Recruiting about 60 new members since 2016

Doubling scientific publications from 369 in 2016 to 746 in 2022

, which provide advanced instrumentation and biostatistics and bioinformatics support for researchers, and providing nearly $6 million in pilot grants since 2015 that have propelled collaborative projects

, which provides training from the high school through faculty levels and includes the only 

Expanding training opportunities in cancer health disparities through the NCI-funded 

Florida-California Cancer Research, Education and Engagement Health Equity Center

Bolstering community outreach by engaging faith-based, farming and underserved communities in cancer prevention and awareness and using a novel 

All of this comes as cancer is at the forefront in Florida, with a major expansion in state funding appropriated by the Florida Legislature with the support of Gov. Ron DeSantis and new research initiatives championed by First Lady Casey DeSantis.

, senior vice president for health affairs at UF and president of UF Health, said, “NCI designation is a momentous development for the UF Health system, recognizing the UF Health Cancer Center’s extraordinary accomplishments in cancer research, clinical care, education and community outreach. This milestone is a strong testament to the advanced, evidence-based cancer care we provide for the patients we serve, and it will ensure we can continue to reach new frontiers in cancer research.”

With one historic milestone met, center leaders are looking ahead. More space for cancer researchers on campus in the 

Malachowsky Hall for Data Science & Information Technology

, expected to open this summer, will help the center add faculty, with the aim of increasing cancer research funding two- to threefold over the next decade. The center will continue to collaborate with the other NCI-designated cancer centers based in Florida to ensure Floridians have access to the latest discoveries and most advanced care close to home. And it will strengthen new collaborations, such as the one formed with colleagues at 

The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

, which is unraveling RNA biology to develop new treatments.

The NCI-designation status is rewarding, said 

, deputy director of the Cancer Center and the Price Eminent Scholar and professor in the division of hematology and oncology at the UF College of Medicine. But the best part is what it means for patients and the future, he said.

“Designation is an assurance to our patients and community that our clinical research programs are making a major impact on cancer outcomes,” Wingard said. “It is an important recognition that we are on the right path to usher in a future in which the expected outcome of a cancer diagnosis is a cure and everyone in our community has ready access to personalized care.”

The Cancer Center Support Grant from the National Cancer Institute will provide funding to strengthen, enhance and increase the UF Health Cancer Center’s leading-edge cancer research over the next five years.

Cancer research educations programs for high school students through faculty

Increased annual peer-reviewed research grant funding from $21 million to $32.6 million

Secured new space commitments of 44,000 square feet

Articles

The University of Florida Health Cancer Center has received prestigious designation from the National Cancer Institute, or NCI, and joins the ranks of the country’s most distinguished cancer centers, becoming the 72nd in the United States and the only one in North Central Florida.

UF Health Cancer Center Achieves National Cancer Institute Designation

Pancreatic cancer often lurks as a silent disease. With no known symptoms, it can progress undetected and spread to other organs.

According to the National Cancer Institute, more than 60,000 Americans will be diagnosed with pancreatic cancer this year, and only about 1 in 10 of those diagnosed will survive the next five years. The disease ranks as the third leading cause of cancer deaths in the U.S. because it is rarely detected in the early stages when treatment options are most effective.

Pancreatic cancer’s stealth-like nature has the attention of University of Florida scientists, who have discovered a way to reverse a key cellular process involved in its progression.

UF researchers identified two small molecules that inhibit precancerous cell progression. The molecules also reversed a process known as acinar ductal metaplasia, or ADM, which precedes pancreatic cancer.

“To our knowledge, this is the first time researchers have been able to pharmacologically reverse ADM,” said 

, the study’s senior author and chair of the department of pharmaceutics in the UF College of Pharmacy, part of UF Health, the university’s academic health center. “With these compounds, we could potentially treat a pancreatic cancer patient at an earlier stage of the disease and hopefully improve the treatment options available.”

ADM often occurs when inflammation is present. It is a defense mechanism to avoid having the pancreas make too many digestive enzymes and destroy itself. During ADM, stable, enzyme-making acinar cells turn into protective ductal cells that line the pancreatic duct. If certain genes mutate during the transition, then the cells can become precancerous and eventually develop into cancer.

To study ADM, UF scientists built a laboratory model using animal cells with pancreatic cancer and tissue from a healthy human. They introduced the cells to two compounds — one of which was developed by Chenglong Li, Ph.D., the Nicholas Bodor Professor in Drug Discovery in the UF College of Pharmacy. The ductal cells responded by changing back to acinar cells. Pancreatic cancer can be prevented when acinar cells are maintained in their natural state.

“The findings are significant because we have now demonstrated that ADM can be reversed using drugs,” said Schmittgen, who also serves as the V. Ravi Chandran Professor of Pharmaceutical Sciences in the UF College of Pharmacy. “This research may lead to developing treatments for patients who are at a high risk for pancreatic cancer development.”

Schmittgen hopes this discovery will encourage scientists to think about new ways to treat pancreatic cancer by manipulating ADM. Future research will involve testing other compounds in collaboration with Hendrik Luesch, Ph.D., a co-author of the study and a professor and chair of medicinal chemistry and the Debbie and Sylvia DeSantis Chair in Natural Products Drug Discovery and Development in the UF College of Pharmacy. These compounds may prove to be more effective, as scientists seek new treatments for a disease with very few treatment options.

Pharmacological Inhibition and Reversal of Pancreatic Acinar Ductal Metaplasia

,” was published in the journal Cell Death Discovery.

Pancreatic cancer often lurks as a silent disease. With no known symptoms, it can progress undetected and spread to other organs.


University of Florida Health

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UF Health Cancer Center Achieves National Cancer Institute Designation

UF Discovery Could Lead to Earlier Pancreatic Cancer Treatments