Suresh S. Ramalingam, MD, FACP, FASCO, director, Lung Cancer Program, Winship Cancer Institute of Emory University, professor, assistant dean, Roberto C. Goizueta Distinguished Chair for Cancer Research, director, Division of Medical Oncology, Department of Hematology and Medical Oncology, Emory University School of Medicine, discusses ongoing trials investigating osimertinib (Tagrisso) combination approaches in non-small cell lung cancer (NSCLC).

Osimertinib is considered the standard of care in the frontline setting for patients with NSCLC, and by exploring combinations, researchers hope to reduce resistance to the agent, Ramalingam says. The phase 3 FLAURA2 trial (NCT04035486) is examining the chemotherapy with or without osimertinib in the first-line treatment of patients with 

Additionally, a phase 2 trial (NCT04965090) is exploring combination amivantamab (Rybrevant) and lazertinib (Leclaza) as a first-line therapy in patients with NSCLC harboring 

 mutations, Ramalingam continues. Another potential combination for osimertinib is the antibody-drug conjugate patritumab deruxtecan (U3-1402), and there are ongoing efforts study the tandem, Ramalingam explains. The key of upcoming research will be to find optimal combinations to improve upon outcomes of osimertinib alone, Ramalingam concludes.

Funding from Daiichi Sanyko. Content Developed Independently by OncLive.

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Suresh S. Ramalingam, MD, FACP, FASCO, discusses ongoing trials investigating osimertinib combination approaches in non-small cell lung cancer.


Dr. Ramalingam on Investigating Osimertinib Combination Approaches in NSCLC

Suresh Ramalingam, MD, professor of Hematology and Medical Oncology at Emory School of Medicine and deputy director of Winship Cancer Institute, discusses first-line treatment with single-agent osimertinib in patients with EGFR-mutated non—small cell lung cancer (NSCLC).

As part of a phase I study, 60 patients with EGFR-mutated NSCLC received 80 or 160 mg of frontline osimertinib, which inhibits T790M mutation, a known driver of resistance to EGFR TKI. Updated efficacy data, reported at the ELCC meeting, demonstrated a response rate of around 76% in patients who received frontline osimertinib. The median duration of response has not yet been reached in the group receiving the 80 mg dose of osimertinib, as the majority of patients included in the study are still continuing to receive therapy, says Ramalingam. The median duration of response was 16.7 months in the patient group that receiving the 160 mg dose.

The median progression-free survival (PFS) was 19.3 months for patients receiving osimertinib at 160 mg once daily (n = 30) and was not yet reached for patients receiving the 80 mg dose (n = 30). This PFS is significant when compared to existing therapies for EGFR-mutated NSCLC, which have a the median PFS of around 9 to 13 months, says Ramalingam.

The regimen was well tolerated and most toxicities were grade I or II, he adds.

Osimertinib is currently approved by the FDA for patients with advanced EGFR T790M mutation—positive NSCLC who are resistant to EGFR TKI.

View more from the 2016 European Lung Cancer Conference

Suresh Ramalingam, MD, professor of Hematology and Medical Oncology at Emory School of Medicine and deputy director of Winship Cancer Institute, discusses first-line treatment with single-agent osimertinib in patients with EGFR-mutated nonâ€“small cell lung cancer (NSCLC).

Suresh Ramalingam, MD,

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