Srikala Sridhar, MD, MSc, medical oncologist, Princess Margaret Hospital, head of GU Medical Oncology Site Group, and assistant professor of Medicine, University of Toronto, Canada, discusses the results of a single arm phase II trial examining nab-paclitaxel (Abraxane) as a secondary treatment for urothelial cancer.

The trial enrolled 48 patients with metastatic urothelial cancer who had progressed on a cisplatin-based chemotherapy. All patients on the trial received nab-paclitaxel every 3 weeks at 260 mg/m

 with scans repeated every 6 weeks to assess response.

In the evaluable patients, the partial response rates were 32%. Overall, the median progression-free survival was 6 months and median overall survival was 10.8 months. These results are very impressive for a single-agent with tolerable toxicity in the second-line setting, expresses Sridhar.

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Srikala Sridhar, MD, MSc, from the University of Toronto, Canada, discusses the results of a single arm phase II trial examining nab-paclitaxel as a secondary treatment for urothelial cancer.

Srikala Sridhar, MD, MSc

Articles

Dr. Sridhar on Nab-Paclitaxel in Urothelial Cancer