Lecia V. Sequist, MD, MPH, the Landry Family Associate Professor of Medicine at Harvard Medical School, and director, Center for Innovation in Early Cancer Detection, Massachusetts General Hospital, discusses the importance of implementing broad molecular testing in lung cancer.

Historically, molecular testing in lung cancer has mainly sought out 

 alterations to inform treatment decisions, explains Sequist. However, other mutations have been shown to play critical roles in treatment selection as well. As such, patients who present with metastatic or advanced stage disease should undergo broad panel genetic testing to potentially detect less common alterations, such as 

 mutations are commonly found in the exon 20 section of the gene and has an analogous protein structure to EGFR. As such, patients with 

 mutations are often treated with similar agents asthose used for patients with 

 exon 20 mutations. Moreover, the therapies have shown activity in both genotypes, Sequist concludes.

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Lecia V. Sequist, MD, MPH, discusses the importance of implementing broad molecular testing in lung cancer. 
  


Lecia Sequist, MD, MPH

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Dr. Sequist on the Importance of Broad Molecular Testing in Lung Cancer