Francesca Aroldi, clinical research fellow, University of Oxford, discusses the early efficacy data with RP2 in advanced solid tumors.

, initial findings from the dose-exploration portion of 

 were presented. The results demonstrated encouraging clinical activity with single-agent RP2, a genetically modified herpes simplex-1 oncolytic, says Aroldi. 

Furthermore, 2 heavily pretreated patients with immune-insensitive disease had ongoing partial responses at 9 months, says Aroldi. One patient had esophageal cancer and the other had uveal melanoma. Notably, 1 patient with pretreated mucoepidermoid carcinoma had an ongoing complete response, Aroldi says. 

Additionally, one patient with microsatellite-stable colorectal adenocarcinoma who was pretreated with chemotherapy and a vaccine appears to be responding to RP2 based on second CT scan findings, Aroldi explains. 

The dose-expansion portion of the trial has enrolled 10 patients and will evaluate RP2 in combination with nivolumab (Opdivo). 

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Francesca Aroldi, discusses the early efficacy data with RP2 in advanced solid tumors.  




Francesca Aroldi

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Early Efficacy Data With RP2 in Advanced Solid Tumors