Anna Farago, MD, PhD, Massachusetts General Hospital Cancer Center, instructor of Medicine at Harvard Medical School, discusses opportunities for the development of biomarkers for patients with small cell lung cancer (SCLC).

There was a panel of patient-derived xenograft (PDX) models of SCLC, which were developed from circulating tumor cells (CTC) using the CTC-iChip and some of them were developed from biopsy specimens.

There is hope that having these laboratory models of the patients with SCLC will give researchers the opportunity to investigate proposed biomarkers of sensitivity to other drugs in lung cancer.

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Dr. Farago on Opportunities to Investigate Biomarkers for Small Cell Lung Cancer

Anna Farago, MD, PhD, assistant, Medicine, Massachusetts General Hospital Cancer Center, and instructor, Medicine, at Harvard Medical School, discusses the combination of olaparib (Lynparza) and temozolomide (Temodar) for patients with small cell lung cancer (SCLC).

There is a phase I study investigating the combination of olaparib and temozolomide in patients with SCLC who have had progression after 1 prior line of platinum-based chemotherapy, explains Farago. This was designed as a 3 + 3 dose-escalation study, which escalated patients through 4 doses of the combination therapy.

The doses were found to be relatively tolerable, states Farago. The progression-free survival was 5.6 months with the median duration of treatment for patients being 5 months with some treated up to 1 year.

Anna Farago, MD, PhD, assistant, Medicine, Massachusetts General Hospital Cancer Center, and instructor, Medicine, at Harvard Medical School, discusses the combination of olarparib (Lynparza) and temozolomide (Temodar) for patients with small cell lung cancer (SCLC).

Anna Farago, MD, PhD

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Dr. Farago on Opportunities to Investigate Biomarkers for Small Cell Lung Cancer

Dr. Farago on Combination of Olaparib and Temozolomide in Small Cell Lung Cancer