Andrew Kuykendall, MD

Articles

Real-World Data in Myelofibrosis: Bridging the Gap Between Clinical Trials and Practice

February 21st 2025

Panelists discuss the types of questions that real-world (RW) data can answer in comparison to with clinical trial data, and how it they can complement clinical findings in treatment decision-making.

Advancing Myelofibrosis Treatment: Personalized Strategies with Fedratinib and Ruxolitinib

February 21st 2025

Panelists discuss data from the FREEDOM2 trial and its sub-analysis on low platelet count with fedratinib (FEDR), as well as the pooled analysis of the COMFORT-I/-II trials on ruxolitinib (RUX) for myelofibrosis.

Personalizing Therapy in Myelofibrosis: Insights from Key Clinical Trials

February 14th 2025

Panelists discuss how they select personalized therapy for patients with myelofibrosis (MF) based on current data, considering factors such as disease characteristics and patient-specific factors.

Treatment Goals for Myelofibrosis

February 14th 2025

Panelists discuss their overall treatment goals for myelofibrosis (MF), the role of transplant within their practice, and the benefits and challenges associated with transplantation, as well as how they determine which patients are best suited for this approach.

An Overview to Myelofibrosis and Disease Risk

February 7th 2025

Panelists discuss myelofibrosis (MF) and its diagnostic workup, including how patients with primary MF present, the criteria required for diagnosis, and any additional biomarkers or criteria examined in practice.

Future Considerations for Polycythemia Vera Management: Takeaways from ASH 2024

February 7th 2025

Panelists discuss noteworthy updates in polycythemia vera (PV) from ASH 2024, explore the future of PV treatment, highlight the greatest unmet needs, and discuss how ongoing investigational therapies aim to address these gaps. They also share clinical pearls for community oncologists in managing PV.

Considerations for Polycythemia Vera Management: Patient Monitoring, Outcomes, and Risks

February 3rd 2025

Panelists discuss monitoring parameters when treating patients with polycythemia vera (PV), including what to assess, typical outcomes, and when treatment should be switched due to ineffectiveness. Dr Kuykendall to Dr Gangat: Panelists explore the risk of PV progression/transformation, risk factors for progression, and how the data influence patient care and treatment choices in practice.

Interferon Real- World Treatment Patterns in PV

February 3rd 2025

Panelists discuss real-world treatment patterns for ropeginterferon alfa-2b (Ropeg alfa-2b) in the management of polycythemia vera (PV).

Evolving Treatment Strategies in Polycythemia Vera: Insights Ffrom Trials and Real-World Evidence

January 24th 2025

Panelists discuss how their treatment approach has evolved based on the efficacy and safety profiles from recent trials, how updated data align with or challenge NCCN Guidelines, and the clinical implications of real-world evidence. Dr Harrison explores treatment patterns, blood count control, and the decision to switch from hydroxyurea (HU) to ruxolitinib (RUX) therapy in polycythemia vera (PV).

Safety Considerations for PV Therapy

January 24th 2025

Panelists discuss the safety profiles of therapies for polycythemia vera (PV) and the safety considerations they take into account when determining which patients are best suited for these treatments.

Interferon Therapy in PV

January 17th 2025

Panelists discuss additional data supporting the use of alternative agents and treatment pathways for polycythemia vera (PV), including the role of ropeginterferon alfa-2b (Ropeg alfa-2b) based on findings from the PROUD-PV /CONTINUATION-PV studies.

JAK Inhibition in Polycythemia Vera: Treatment Updates

January 17th 2025

Panelists discuss the role of JAK inhibition in the treatment of polycythemia vera (PV), focusing on the latest efficacy data for ruxolitinib (RUX) from studies such as RUX vs best available therapy (BAT) in PV and the MAJIC-PV trial, highlighting its impact on treatment outcomes.

Cytoreductive Therapy in PV Treatment Paradigm

January 2nd 2025

Panelists discuss how cytoreductive therapy fits into the treatment paradigm for polycythemia vera (PV), highlighting key findings from the CYTO-PV study and its subanalysis, which inform their treatment decisions for patients with PV.

Practice Takeaways: Treating MF Patients—Key Strategies for Community Providers

December 25th 2024

Panelists share their closing thoughts and practice pearls, offering key insights and takeaways for community oncologists based on discussing treatment strategies in myelofibrosis.

Initial Treatment Strategies for Polycythemia Vera

December 23rd 2024

Panelists discuss how they approach the evaluation and diagnosis of polycythemia vera (PV), including key clinical manifestations, and how they assess disease risk to determine initial treatment strategies based on NCCN guidelines, considering factors that differentiate low-risk from high-risk PV.

Clinical Insights on Managing Ruxolitinib Cytopenias: Patient-Focused Approach

December 18th 2024

Panelists discuss the patient and disease characteristics influencing the decision to dose-reduce ruxolitinib vs switching therapy. They share their typical sequencing approach after first-line ruxolitinib, including whether a washout period or overlap is required.

Challenges With Defining “Ruxolitinib Failure” or Suboptimal Response to Ruxolitinib in MF

December 11th 2024

Panelists discuss how they define “ruxolitinib failure” and a suboptimal response, when they consider switching from first-line ruxolitinib, and how they differentiate between myelofibrosis-induced and JAK-induced cytopenias.

Dr Kuykendall on the Advantages of Treatment With Momelotinib in Myelofibrosis

December 10th 2024

Andrew Kuykendall, MD, discusses the advantages of treatment with momelotinib vs older-generation JAK inhibitors in myelofibrosis.

Tackling Complex Clinical Scenarios: MF Patients With Thrombocytopenia and Anemia

December 4th 2024

Panelists discuss the latest data on pacritinib’s effects on anemia and bicytopenia, and share their treatment approaches for patients with myelofibrosis who present with both thrombocytopenia and anemia.

Clinical Perspectives: Firstline Treatment Landscape in Higher-Risk MF

November 27th 2024

Panelists discuss how frequently patients with newly diagnosed myelofibrosis present with moderate or severe thrombocytopenia or both anemia and thrombocytopenia. They discuss how these factors and other disease characteristics like spleen size and constitutional symptoms influence their treatment approach and selection of JAK inhibitors.