Akihiko Shimomura, MD, PhD, Department of Breast and Medical Oncology, Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan, discusses the HERB TEA trial (JCOG1607) in patients with HER2-positive breast cancer.

HERB TEA trial is a phase III study comparing ado-trastuzumab emtansine (T-DM1; Kadcyla) with trastuzumab (Herceptin), pertuzumab (Perjeta), and docetaxel in elderly patients with advanced HER2-positive breast cancer. The rationale for this study, Shimomura says, is the lack of tolerable options for patients over 65 years of age. Traditionally, systemic chemotherapy with an anti-HER2 therapy is the standard of care for patients with HER2-positive advanced breast cancer.

Patients enrolled in the trial will be randomized to receive trastuzumab with pertuzumab and docetaxel or T-DM1. The primary endpoint of HERB TEA is overall survival, and secondary endpoints are progression-free survival, response rate, adverse events (AEs), breast cancer-related death, and quality of life (QoL). AEs and QoL are of particular importance in this subgroup, as they often experience intolerable physical and mental side effects from traditional treatment.

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Akihiko Shimomura, MD, PhD, Department of Breast and Medical Oncology, Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan, discusses the HERB TEA trial (JCOG1607) in patients with HER2-positive breast cancer.
 

Akihiko Shimomura, MD, PhD

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