Ruth Aiwu He, MD, PhD, scientific lead in liver and biliary cancers at Georgetown-Lombardi Comprehensive Cancer Center, discusses the results of the LEGACY study in patients with hepatocellular carcinoma (HCC).

The LEGACY study was a retrospective analysis of patients with early-stage HCC who received Y-90 glass microspheres (TheraSphere), according to He. In the overall cohort, Y-90 demonstrated a best overall response rate of 88%, with a complete response rate of 83%, says He.

Additionally, the therapy resulted in prolonged disease control, and the 3-year overall survival rate in patients with transplant or resection following Y-90 was 93%, says He. Overall, the results of the study appear to be quite promising, He concludes.

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Ruth Aiwu He, MD, PhD, discusses the results of the LEGACY study in patients with hepatocellular carcinoma.

Dr. He on the Results of the LEGACY Study Examining Y-90 in HCC

Aiwu Ruth He, MD, PhD, associate professor of medicine, Georgetown-Lombardi Comprehensive Cancer Center, discusses the combination regimen of bevacizumab (Avastin) and atezolizumab (Tecentriq) in patients with advanced-stage hepatocellular carcinoma (HCC).

Results show that patients with HCC who received this combination experienced an improvement in progression-free and overall survival (OS) compared with sorafenib (Nexavar). The median OS for bevacizumab and atezolizumab was not estimable compared with 13.2 months for patients who received sorafenib. Additionally, the median progression-free survival (PFS) with atezolizumab/bevacizumab was 6.8 months compared with 4.3 months for sorafenib.

This combination therapy could become a frontline systemic therapy for advanced-stage HCC, says He. A randomized phase III trial evaluating the combination is ongoing.

Aiwu Ruth He, MD, discusses the combination regimen of bevacizumab and atezolizumab in patients with advanced-stage hepatocellular carcinoma.
 

Aiwu Ruth He, MD

Articles

Dr. He on the Results of the LEGACY Study Examining Y-90 in HCC

Dr. He on Future Treatment for Patients With Hepatocellular Carcinoma